Theory in the Pathophysiology of Carcinogenesis

Contrasting Profiles of High Grade Gliomas as Malignant Transformation of the Individual Neoplastic Astrocyte

Author(s): Lawrenc M. Agius

Pp: 9-15 (7)

Doi: 10.2174/978160805266011101010009

* (Excluding Mailing and Handling)

Abstract

Dimensions of further incremental progression in infiltration of the central nervous system by high grade glioma are symptomatic of the overall implications of the individual astrocyte that undergoes a malignant change in the first instance. Such malignant transformation is faithfully incorporated within dimensional context of an infiltrative tumor front that encompasses further malignant transformation in its own right. It is the significant role of several aggregates of neoplastic astrocytes that allows for the amplification of the injury beyond the development of infiltrative attributes and as a consequential contrast of attributes between genotype and phenotype characterization. The individual malignant astrocyte is indeed a specific form of malignancy that incorporates the dimensions of an infiltrative front evidenced by whole aggregates of such individual malignant astrocytes. It is in terms of ongoing amplification that the developmental dimensions of injury are translated into onset and progression of the malignant transformation process, and as further evidenced by field effect in carcinogenesis.

Hence, infiltrativeness by neoplastic astrocytes is both individually manifested and also an aggregate phenomenon in subsequent reconstitution of the injury at cellular and tissue level of operative contrasting influence.


Keywords: gliomas, individual astrocyte, infiltration, injury.

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