Rheumatoid arthritis is a severe systemic autoimmune disorder with limited
option available for treatment and no curative therapy available at present. Rheumatoid
arthritis manifests clinically through polyarthralgia related to joint dysfunction, which
triggers the autoimmune responses associated with antibodies against the selfneoepitopes and causes the chronic arthritic attack. Bone destruction is an important
feature to understand the pathology of rheumatoid arthritis, which may lead to a serious
concern for the patient for living a quality life. Available drugs for rheumatoid arthritis
such as methotrexate, hydroxychloroquine, and sulfasalazine exert effects on bone
metabolism in immune cells and cytokines that result in relieving pain, improving the
quality of life but still, the chronic teratogenic and toxic effects are challenging in
management of anti-arthritic drugs. This chapter reviews the current trend of bioactive
compounds for the treatment of rheumatoid arthritis, which may lead to the
development of novel anti-rheumatoid arthritis agents.
Keywords: Adjuvant-induced arthritis, Alkaloids, Anthocyanin, Bone destruction, Crystal-induced arthritis, Cytokines, Dietary therapeutics, Fatty acids, Fatty acid, Flavonoids, Immunosuppression, Inflammation, Polyphenols, Rheumatoid arthritis, Saponins, Triterpenoids.