Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part II

Targeted Drug Delivery System to Cell and Cell Organelles

Author(s): Kenny Shane P. Alojado and Erwin Martinez Faller * .

Pp: 202-219 (18)

DOI: 10.2174/9789815036541122010013

* (Excluding Mailing and Handling)

Abstract

Today, massive investigations have been undertaken to boost the targetoriented distribution of drugs to maximize their therapeutic index. Cell targeting drug delivery is a good candidate in exhibiting therapeutic effect to severe diseases such as cancer; The extent to which the drug can achieve its intended goal is of the utmost importance. This system is designed to aid a drug's ability to pass an obstacle that it might not otherwise be able to pass through regular means; therefore, their impact is pharmacokinetic. The drug's pharmacological effects should remain untouched, like its pharmacodynamic structure. In some cases, the pharmaceutical delivery mechanism has an effect on how the drug appears to work. Drugs must overcome numerous hurdles that are on the way to the target tissue from the administration site. In certain cases, a physically defensive barrier around the drug cargo is created to help the drug navigate over certain barriers. The need for selective medication distribution has, therefore, been well acknowledged in current drug therapy. Thus, in this chapter, we discuss the different organelle targeting drug delivery systems and studies involved in it. 


Keywords: Cell organelles, Targeted drug delivery, Vesicle based drug delivery.

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