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Systemic Lupus Erythematosus: A Systematic Approach to Arthritis of Rheumatic Diseases

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Neuropsychiatric Systemic Lupus Erythematosus (NP-SLE)

Author(s): Syuichi Koarada* and Yuri Shirahama

Pp: 311-321 (11)

DOI: 10.2174/9789815050653122040011

* (Excluding Mailing and Handling)

Abstract

Neuropsychiatric systemic lupus erythematosus (NP-SLE) is one of the most
serious organ complications of SLE, affecting health, quality of life, and prognosis of
life in patients with SLE. Neurological symptoms are various. Among the pathological
conditions of SLE, those including neurologic syndromes of the central nervous
system, peripheral nervous system, and diffuse psychiatric and neuropsychiatric
syndrome are called NP-SLE in the American College of Rheumatology (ACR)
nomenclature. In NP-SLE, such a variety of pathophysiology should be considered
when selecting a treatment. In this article, we describe the neurological lesions of SLE
with illustrations.

Keywords: Cerebral atrophy, Diffuse cerebral edema, Neuropsychiatric-SLE (NP-SLE), Posterior reversible encephalopathy syndrome, Systemic lupus erythematosus (SLE).

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