Current Advances in Breast Cancer Research: A Molecular Approach

An Overview of Genetic, Proteomic and Metabolomic Biomarkers in Breast Cancer

Author(s): Tarjani Agrawal

Pp: 61-103 (43)

Doi: 10.2174/9789811451447120010006

* (Excluding Mailing and Handling)

Abstract

The molecular techniques play an important role in the diagnosis and treatment of breast cancer. Recent advances in molecular techniques have contributed significantly to understanding tumor biology, tumor heterogeneity, identification of different biomarkers, and discovery of new therapeutic measures and improvement in overall survival, especially in specific subsets of breast cancer. There are other challenging areas in breast cancer research, such as the development of treatments for the highly aggressive triple-negative breast cancer subtype, chemotherapy-resistant cancer stem cell subpopulation, and male breast cancer. New knowledge emerging from researches in genetics, proteomics, and metabolomics offers a promising opportunity for the identification of new biomarkers, and to find novel targets that could facilitate future therapeutic interventions.


Keywords: Breast cancer, Biomarker, Genetics, Metabolomics, Proteomics.

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