Journal: Current Psychopharmacology
Guest editor(s):Dr. Dr Prashant Tiwari
Co-Guest Editor(s): Dr. Sunil Kumar Kadiri,Dr. Pratap Kumar Sahu

Introduction

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the current pharmacotherapeutic approaches to treating mental illnesses as well as drug delivery approaches that have improved existing therapies. Approaches to improve drug bioavailability, provide controlled release of therapeutics, and enable drug targeting to the central nervous system (CNS) will be highlighted.

Keywords

Drug discovery, brain targeting, schizophrenia, bipolar disorder, Alzheimer’s disease, psychiatric disorders, neurotrophic factors, target occupancy

Sub-topics

Drug Design strategies Past, Present, Future to address neuro-psychiatric disorders
AI and machine learning methods to scale-up screening of drugs towards neuronal cells
Natural products in drug discovery: obstacles and opportunities
Drug reprofiling and strategies to deliver drugs against neurodegenerations
Contemporary advances and perspectives in neuro-psychiatric disorders drug design
Target based cellular and molecular models for neuropsychiatric drug discovery
Impact of Genetic Variation on the pharmacokinetics of Neuroleptic drugs.
Progress in drug delivery systems to enhance bioavailability and permeability of drugs to penetrate blood brain barrier (BBB).