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Current Drug Research Reviews


ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Case Report

Transient Left Ventricular Acute Failure after Cocaine Use

Author(s): Michaël Cardinale*, Pierre Esnault , Johan Schmitt and Eric Meaudre

Volume 11, Issue 2, 2019

Page: [142 - 144] Pages: 3

DOI: 10.2174/2589977511666190716111303


Background: Cocaine is one of the most widely used illicit drugs, and it is the most common cause of drug-related death. The association of cocaine use with acute heart failure is a rare occurrence.

Case Report: We report the case of a 31 years-old woman who presented Takotsubo cardiomyopathy with severe cardiogenic shock after cocaine abuse. That required the use of high doses of positive inotropic amines and mechanical ventilation. The evolution was quickly favorable after the cessation of cocaine.

Discussion: Takotsubo cardiomyopathy is often related to a stressful trigger, and several cases have been described with the use of several psychostimulants. As such, it is not surprising that cocaine use can be associated with the development of Takotsubo cardiomyopathy when it results in excess release of catecholamines and excitation of adrenergic receptors.

Conclusion: In critical care unit, Takotsubo cardiomyopathy is a rare complication of cocaine abuse. This etiological diagnosis can be difficult especially in the absence of the concept of toxic intake as it was initially the case for our patient, but the treatment does not differ from other causes of cardiomyopathy and Cessation of cocaine use has been associated with improvement in cardiac function.

Keywords: Acute heart failure, cocaine abuse, Takotsubo cardiomyopathy, cardiogenic shock, mechanical ventilation, psychostimulants.

Graphical Abstract
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