Background: Autoimmune diseases result from the interplay of cellular effectors like T and B cells, regulatory cells in addition to molecular factors like cytokines and regulatory molecules.
Methods: Different electronic databases were searched in a non-systematic way to find out the literature of interest.
Results: Pathogenesis of autoimmune diseases involves typical factors such as genetic background including HLA and non HLA system genes, environmental factors such as infectious agents and inflammatory cells mainly T and B lymphocytes abnormally activated leading to immune dysfunction. Other recently reported less typical factors such as micro-RNAs, circular RNAs, myeloperoxidase, vimentine and microbiome dysbiosis seem to be potential target therapies.
Conclusion: We aimed in this manuscript to review common factors in the pathogenesis of autoimmune diseases.
[http://dx.doi.org/10.1146/annurev-immunol-020711-075013] [PMID: 22224773]
[http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.049] [PMID: 29605448]
[http://dx.doi.org/10.1186/s13075-015-0666-6] [PMID: 26059223]
[http://dx.doi.org/10.1146/annurev.bi.63.070194.002021] [PMID: 7979242]