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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

What Can We Learn from Sarcopenia with Curarisation in the Context of Cancer Surgery? A Review of the Literature

Author(s): Georges Samouri, Alexandre Stouffs, Lionel V. Essen, Olivier Simonet, Marc De Kock and Patrice Forget*

Volume 25 , Issue 28 , 2019

Page: [3005 - 3010] Pages: 6

DOI: 10.2174/1381612825666190705185033

Price: $65

Abstract

Introduction: The monitoring of the curarisation is a unique opportunity to investigate the function of the neuromuscular junction (NMJ) during cancer surgery, especially in frailty-induced and age-related sarcopenia.

Method: We conducted a comprehensive literature review in PubMed, without any limit of time related to frailty, sarcopenia, age and response to neuromuscular blockers in the context of cancer surgery.

Results: Several modifications appear with age: changes in cardiac output, a decrease in muscle mass and increase in body fat, the deterioration in renal and hepatic function, the plasma clearance and the volume of distribution in elderly are smaller. These changes can be exacerbated in cancer patients. We also find modifications of the NMJ: dysfunctional mitochondria, modifications in the innervation of muscle fibers and motor units, uncoupling of the excitation-contraction of muscle fibers, inflammation.

Neuromuscular blocking agents (NMBAs) compete with acetylcholine and prevent it from fixing itself on its receptor. Many publications reported guidelines for using NMBAs in the elderly, based on studies comparing old people with young people.

No one screened frailty before, and thus, no studies compared frail elderly and non-frail elderly undergoing cancer surgery.

Conclusion: Despite many studies about curarisation in the specific populations, and many arguments for a potential interest for investigation, no studies investigated specifically the response to NMBAs in regard of the frailty-induced and age-related sarcopenia.

Keywords: Frailty, sarcopenia, neuromuscular junction, neuromuscular blockers, cancer surgery, muscle mass.

[1]
Chow W, Ko C, Rosenthal R, Esnaola N. ACS NSQIP®/AGS best practice guidelines: Optimal preoperative assessment of the geriatric surgical patient. The American Geriatrics Society.
[2]
Comfort A Ageing: The Biology of Senescence. 2nd ed. 1964.
[3]
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet 2013; 381(9868): 752-62.
[http://dx.doi.org/10.1016/S0140-6736(12)62167-9] [PMID: 23395245]
[4]
Fried LP, Tangen CM, Walston J, et al. Cardiovascular health study collaborative research group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001; 56(3): M146-56.
[http://dx.doi.org/10.1093/gerona/56.3.M146] [PMID: 11253156]
[5]
Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006; 54(6): 991-1001.
[http://dx.doi.org/10.1111/j.1532-5415.2006.00745.x] [PMID: 16776798]
[6]
Eeles EM, White SV, O’Mahony SM, Bayer AJ, Hubbard RE. The impact of frailty and delirium on mortality in older inpatients. Age Ageing 2012; 41(3): 412-6.
[http://dx.doi.org/10.1093/ageing/afs021] [PMID: 22391613]
[7]
Coelho T, Paúl C, Gobbens RJJ, Fernandes L. Frailty as a predictor of short-term adverse outcomes. PeerJ 2015; 3e1121
[http://dx.doi.org/10.7717/peerj.1121] [PMID: 26246968]
[8]
Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006; 35(5): 526-9.
[http://dx.doi.org/10.1093/ageing/afl041]
[9]
Rosenberg IH. Summary comments. Am J Clin Nutr 1989; 50: 1231-3.
[http://dx.doi.org/10.1093/ajcn/50.5.1231]
[10]
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis—report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39(4): 412-23.
[http://dx.doi.org/10.1093/ageing/afq034] [PMID: 20392703]
[11]
Boyd E. Normal variability in weight of the adult human liver and spleen. Arch Pathol (Chic) 1933; 16: 350-72.
[12]
Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature 2010; 464(7288): 529-35.
[http://dx.doi.org/10.1038/nature08983] [PMID: 20336135]
[13]
Florini JR, Ewton DZ, Magri KA. Hormones, growth factors, and myogenic differentiation. Annu Rev Physiol 1991; 53: 201-16.
[http://dx.doi.org/10.1146/annurev.ph.53.030191.001221] [PMID: 2042960]
[14]
Lamberts SW. The endocrinology of aging and the brain. Arch Neurol 2002; 59(11): 1709-11.
[http://dx.doi.org/10.1001/archneur.59.11.1709] [PMID: 12433255]
[15]
Lamberts SW, van den Beld AW, van der Lely AJ. The endocrinology of aging. Science 1997; 278(5337): 419-24.
[http://dx.doi.org/10.1126/science.278.5337.419] [PMID: 9334293]
[16]
Attaix D, Mosoni L, Dardevet D, Combaret L, Mirand PP, Grizard J. Altered responses in skeletal muscle protein turnover during aging in anabolic and catabolic periods. Int J Biochem Cell Biol 2005; 37(10): 1962-73.
[http://dx.doi.org/10.1016/j.biocel.2005.04.009] [PMID: 15905114]
[17]
Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010; 464(7288): 520-8.
[http://dx.doi.org/10.1038/nature08982] [PMID: 20336134]
[18]
Miller RA. The aging immune system: primer and prospectus. Science 1996; 273(5271): 70-4.
[http://dx.doi.org/10.1126/science.273.5271.70] [PMID: 8658199]
[19]
Delmonico MJ, Harris TB, Visser M, et al. Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 2009; 90(6): 1579-85.
[http://dx.doi.org/10.3945/ajcn.2009.28047] [PMID: 19864405]
[20]
Clark BC, Issac LC, Lane JL, Damron LA, Hoffman RL. Neuromuscular plasticity during and following 3 wk of human forearm cast immobilization. J Appl Physiol 2008; 105(3): 868-78.
[http://dx.doi.org/10.1152/japplphysiol.90530.2008] [PMID: 18635877]
[21]
Fielding RA, Vellas B, Evans WJ, et al. International Working Group on Sarcopenia. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011; 12(4): 249-56.
[http://dx.doi.org/10.1016/j.jamda.2011.01.003] [PMID: 21527165]
[22]
McLean RR, Shardell MD, Alley DE, et al. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 2014; 69(5): 576-83.
[http://dx.doi.org/10.1093/gerona/glu012] [PMID: 24737560]
[23]
Cawthon PM, Peters KW, Shardell MD, et al. Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci 2014; 69(5): 567-75.
[http://dx.doi.org/10.1093/gerona/glu023] [PMID: 24737559]
[24]
Lexell J, Henriksson-Larsén K, Winblad B, Sjöström M. Distribution of different fiber types in human skeletal muscles: effects of aging studied in whole muscle cross sections. Muscle Nerve 1983; 6(8): 588-95.
[http://dx.doi.org/10.1002/mus.880060809] [PMID: 6646161]
[25]
Farnfield MM, Breen L, Carey KA, Garnham A, Cameron-Smith D. Activation of mTOR signalling in young and old human skeletal muscle in response to combined resistance exercise and whey protein ingestion. Appl Physiol Nutr Metab 2012; 37(1): 21-30.
[http://dx.doi.org/10.1139/h11-132] [PMID: 22148961]
[26]
Chai RJ, Vukovic J, Dunlop S, Grounds MD, Shavlakadze T. Striking denervation of neuromuscular junctions without lumbar motoneuron loss in geriatric mouse muscle. PLoS One 2011; 6(12)e28090
[http://dx.doi.org/10.1371/journal.pone.0028090] [PMID: 22164231]
[27]
O’Neill ED, Wilding JP, Kahn CR, et al. Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation. Age (Dordr) 2010; 32(2): 209-22.
[http://dx.doi.org/10.1007/s11357-009-9125-0] [PMID: 20431988]
[28]
Edström E, Altun M, Bergman E, et al. Factors contributing to neuromuscular impairment and sarcopenia during aging. Physiol Behav 2007; 92(1-2): 129-35.
[http://dx.doi.org/10.1016/j.physbeh.2007.05.040] [PMID: 17585972]
[29]
Aagaard P, Suetta C, Caserotti P, Magnusson SP, Kjaer M. Role of the nervous system in sarcopenia and muscle atrophy with aging: strength training as a countermeasure. Scand J Med Sci Sports 2010; 20(1): 49-64.
[http://dx.doi.org/10.1111/j.1600-0838.2009.01084.x] [PMID: 20487503]
[30]
Ferrucci L, Cavazzini C, Corsi A, et al. Biomarkers of frailty in older persons. J Endocrinol Invest 2002; 25(10)(Suppl.): 10-5.
[PMID: 12508906]
[31]
Taffett G. Physiology of Aging. In: Cassell C, Ed. Geriatric Medicine An Evidence Based Approach. New York: Springer-Verlage 2003.
[http://dx.doi.org/10.1007/0-387-22621-4_3]
[32]
Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120(4): 437-47.
[http://dx.doi.org/10.1016/j.cell.2005.01.027] [PMID: 15734677]
[33]
McGowan PO, Szyf M. Environmental epigenomics: understanding the effects of parental care on the epigenome. Essays Biochem 2010; 48(1): 275-87.
[http://dx.doi.org/10.1042/bse0480275] [PMID: 20822499]
[34]
Kahn A, Fraga MF. Epigenetics and aging: status, challenges, and needs for the future. J Gerontol A Biol Sci Med Sci 2009; 64(2): 195-8.
[http://dx.doi.org/10.1093/gerona/gln064] [PMID: 19251914]
[35]
Holliday R. Epigenetics: a historical overview. Epigenetics 2006; 1(2): 76-80.
[http://dx.doi.org/10.4161/epi.1.2.2762] [PMID: 17998809]
[36]
Kurokawa K, Mimori Y, Tanaka E, Kohriyama T, Nakamura S. Age-related change in peripheral nerve conduction: compound muscle action potential duration and dispersion. Gerontology 1999; 45(3): 168-73.
[http://dx.doi.org/10.1159/000022081] [PMID: 10202263]
[37]
Banker BQ, Kelly SS, Robbins N. Neuromuscular transmission and correlative morphology in young and old mice. J Physiol 1983; 339: 355-77.
[http://dx.doi.org/10.1113/jphysiol.1983.sp014721] [PMID: 6310088]
[38]
Jang YC, Van Remmen H. Age-associated alterations of the neuromuscular junction. Exp Gerontol 2011; 46(2-3): 193-8.
[http://dx.doi.org/10.1016/j.exger.2010.08.029] [PMID: 20854887]
[39]
Rowan SL, Rygiel K, Purves-Smith FM, Solbak NM, Turnbull DM, Hepple RT. Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle. PLoS One 2012; 7(1)e29082
[http://dx.doi.org/10.1371/journal.pone.0029082] [PMID: 22235261]
[40]
García ML, Fernández A, Solas MT. Mitochondria, motor neurons and aging. J Neurol Sci 2013; 330(1-2): 18-26.
[http://dx.doi.org/10.1016/j.jns.2013.03.019] [PMID: 23628465]
[41]
Peterson CM, Johannsen DL, Ravussin E. Skeletal muscle mitochondria and aging: a review. J Aging Res 2012; 2012194821
[http://dx.doi.org/10.1155/2012/194821] [PMID: 22888430]
[42]
Navarro A, Boveris A. Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease. J Bioenerg Biomembr 2009; 41(6): 517-21.
[http://dx.doi.org/10.1007/s10863-009-9250-6] [PMID: 19915964]
[43]
Ibebunjo C, Chick JM, Kendall T, et al. Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia. Mol Cell Biol 2013; 33(2): 194-212.
[http://dx.doi.org/10.1128/MCB.01036-12] [PMID: 23109432]
[44]
Li H, Kumar Sharma L, Li Y, et al. Comparative bioenergetic study of neuronal and muscle mitochondria during aging. Free Radic Biol Med 2013; 63: 30-40.
[http://dx.doi.org/10.1016/j.freeradbiomed.2013.04.030] [PMID: 23643721]
[45]
Baines HL, Turnbull DM, Greaves LC. Human stem cell aging: Do mitochondrial DNA mutations have a causal role? Aging Cell 2014; 13(2): 201-5.
[http://dx.doi.org/10.1111/acel.12199] [PMID: 24382254]
[46]
Rangaraju S, Notterpek L. Autophagy aids membrane expansion by neuropathic Schwann cells. Autophagy 2011; 7(2): 238-9.
[http://dx.doi.org/10.4161/auto.7.2.14278] [PMID: 21135575]
[47]
Kim HA, Mindos T, Parkinson DB. Plastic fantastic: Schwann cells and repair of the peripheral nervous system. Stem Cells Transl Med 2013; 2(8): 553-7.
[http://dx.doi.org/10.5966/sctm.2013-0011] [PMID: 23817134]
[48]
Delbono O. Neural control of aging skeletal muscle. Aging Cell 2003; 2(1): 21-9.
[http://dx.doi.org/10.1046/j.1474-9728.2003.00011.x] [PMID: 12882331]
[49]
Wang X, Engisch KL, Li Y, Pinter MJ, Cope TC, Rich MM. Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo. J Neurosci 2004; 24(47): 10687-92.
[http://dx.doi.org/10.1523/JNEUROSCI.2755-04.2004] [PMID: 15564585]
[50]
Shear TD, Martyn JAJ. Physiology and biology of neuromuscular transmission in health and disease. J Crit Care 2009; 24(1): 5-10.
[http://dx.doi.org/10.1016/j.jcrc.2008.08.002] [PMID: 19272533]
[51]
Ryan M, Ohlendieck K. Excitation-Contraction uncoupling and sarcopenia. Basic Appl Myol 2004; 14(3): 141-54.
[52]
Spillane J, Higham E, Kullmann DM. Myasthenia gravis. The BMJ 2012; 345e8497
[http://dx.doi.org/10.1136/bmj.e8497]
[53]
Blichfeldt-Lauridsen L, Hansen BD. Anesthesia and myasthenia gravis. Acta Anaesthesiol Scand 2012; 56(1): 17-22.
[http://dx.doi.org/10.1111/j.1399-6576.2011.02558.x]
[54]
de Boer HD, van Egmond J, Driessen JJ, Booij LH. Sugammadex in patients with myasthenia gravis. Anaesthesia 2010; 65(6): 653.
[http://dx.doi.org/10.1111/j.1365-2044.2010.06360.x] [PMID: 20565409]
[55]
Franceschi C, Capri M, Monti D, et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128(1): 92-105.
[http://dx.doi.org/10.1016/j.mad.2006.11.016] [PMID: 17116321]
[56]
Zheng Z, Wang ZM, Delbono O. Insulin-like growth factor-1 increases skeletal muscle dihydropyridine receptor alpha 1S transcriptional activity by acting on the cAMP-response element-binding protein element of the promoter region. J Biol Chem 2002; 277(52): 50535-42.
[http://dx.doi.org/10.1074/jbc.M210526200] [PMID: 12407098]
[57]
Gonzalez-Freire M, de Cabo R, Studenski SA, Ferrucci L. The neuro muscular junction: aging at the crossroad between nerves and muscle. Front Aging Neurosci 2014; 6: 208.
[http://dx.doi.org/10.3389/fnagi.2014.00208] [PMID: 25157231]
[58]
American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharmacists, American College of Chest Physicians Clinical practice. guidelines for sustained neuromuscular blockade in the adult critically ill patient. Am J Health Syst Pharm 2002; 59(2): 179-95.
[http://dx.doi.org/10.1093/ajhp/59.2.179] [PMID: 11826571]
[59]
Matteo RS, Ornstein E, Schwartz AE, Ostapkovich N, Stone JG. Pharmacokinetics and pharmacodynamics of rocuronium (Org 9426) in elderly surgical patients. Anesth Analg 1993; 77(6): 1193-7.
[http://dx.doi.org/10.1213/00000539-199312000-00019] [PMID: 8250312]
[60]
Adamus M, Hrabalek L, Wanek T, Gabrhelik T, Zapletalova J. Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anesthesia. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011; 155(4): 347-53.
[http://dx.doi.org/10.5507/bp.2011.050]
[61]
Baykara N, Solak M, Toker K. Predicting recovery from deep neuromuscular block by rocuronium in the elderly. J Clin Anesth 2003; 15(5): 328-.
[62]
Dubois PE, Gourdin M, Jamart J, Broka SM, Eucher P, D’Hollander A. Early and late parameters describing the offset of neuromuscular blockade are highly intercorrelated. Acta Anaesthesiol Scand 2012; 56(1): 76-82.
[http://dx.doi.org/10.1111/j.1399-6576.2011.02596.x] [PMID: 22150409]
[63]
Parsons HA, Baracos VE, Dhillon N, Hong DS, Kurzrock R. Body composition, symptoms, and survival in advanced cancer patients referred to a phase I service. PLoS One 2012; 7(1)e29330
[http://dx.doi.org/10.1371/journal.pone.0029330] [PMID: 22235285]
[64]
Fearon KC, Glass DJ, Guttridge DC. Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab 2012; 16(2): 153-66.
[http://dx.doi.org/10.1016/j.cmet.2012.06.011] [PMID: 22795476]
[65]
Scott HR, McMillan DC, Crilly A, McArdle CS, Milroy R. The relationship between weight loss and interleukin 6 in non-small-cell lung cancer. Br J Cancer 1996; 73(12): 1560-2.
[http://dx.doi.org/10.1038/bjc.1996.294] [PMID: 8664130]
[66]
Moses AG, Maingay J, Sangster K, Fearon KC, Ross JA. Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: Relationship to acute phase response and survival. Oncol Rep 2009; 21(4): 1091-5.
[PMID: 19288013]
[67]
Scheede-Bergdahl C, Watt HL, Trutschnigg B, et al. Is IL-6 the best pro-inflammatory biomarker of clinical outcomes of cancer cachexia? Clin Nutr 2012; 31(1): 85-8.
[http://dx.doi.org/10.1016/j.clnu.2011.07.010] [PMID: 21855185]

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