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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Selenium Status in Elderly People: Longevity and Age-Related Diseases

Author(s): Harry Robberecht*, Tess De Bruyne, Elisabeth Davioud-Charvet, John Mackrill and Nina Hermans

Volume 25 , Issue 15 , 2019

Page: [1694 - 1706] Pages: 13

DOI: 10.2174/1381612825666190701144709

Price: $65


Background: Selenium (Se) is a trace element active in selenoproteins, which can regulate oxidative stress. It is generally perceived as an import factor for maintaining health in the elderly.

Methods: The goal of this review is to discuss selenium concentration in biological samples, primarily serum or plasma, as a function of age and its relation with longevity. The elemental level in various age-related diseases is reviewed.

Conclusion: Highest selenium values were observed in healthy adults, while in an elderly population significantly lower concentrations were reported. Variables responsible for contradictory findings are mentioned. Risk and benefits of Se-supplementation still remain under debate.

Keywords: Selenium, biological materials, longevity, age-related diseases, oxidative stress, Se-supplementation.

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