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Review Article

克氏锥虫中的氨基酸和多胺膜转运蛋白：生物学功能和药物靶标的评价。

卷 26, 期 36, 2019

页: [6636 - 6651] 页: 16

弟呕挨: 10.2174/0929867326666190620094710

价格: $65

摘要

氨基酸和多胺参与了克氏锥虫寄生虫的相关过程，例如蛋白质合成，抗逆性，生命周期进程，感染建立和氧化还原平衡等。除氨基酸的生物合成途径外，克鲁氏锥虫还具有转运系统，可以从细胞外培养基中主动摄取。对于多胺，摄取是获得这些化合物的独特方法。 TcAAAP蛋白家族在哺乳动物中不存在，其成员负责氨基酸和衍生物的摄取，因此TcAAAP渗透酶不仅是有趣且有希望的治疗靶标，还可以用于指导有毒化合物进入寄生虫。尽管有针对南美锥虫病的治疗方法，但其在慢性病中的有限疗效以及所报道的副作用突出了开发新疗法的迫切需要。新药的发现是一个缓慢且昂贵的过程，即使在临床试验中，新药也会失败。在这种情况下，药物重新定位是世界卫生组织提出的一项有趣且推荐的策略，因为可以大大降低成本和时间。在本文中，氨基酸和多胺的转运及其作为治疗靶标的潜力将得到修订，包括合成药物和药物再利用的实例。

关键词: 克氏锥虫，氨基酸转运，多胺转运，治疗靶标，药物发现，药物重新定位，新疗法，恰加斯病。

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