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Current Clinical Pharmacology


ISSN (Print): 1574-8847
ISSN (Online): 2212-3938

Research Article

Comparison of the Mean Minimum Dose of Bolus Oxytocin for Proper Uterine Contraction during Cesarean Section

Author(s): Siavash Beiranvand, Arash Karimi, Sepideh Vahabi* and Arash Amin-Bidokhti

Volume 14, Issue 3, 2019

Page: [208 - 213] Pages: 6

DOI: 10.2174/1574884714666190524100214


Background: Cesarean section is the most common midwifery operation. The aim of this study is to determine the mean minimum dose of bolus oxytocin for proper uterine contraction during cesarean section.

Methods: Patients were divided into two groups: elective cesarean section (n=41) and cesarean section due to difficulty in labor (n=42 patients). Patients underwent spinal anesthesia and oxytocin infusion was begun at 30 drops per minute (20 units of oxytocin per 1000 cc serum), and was also administered as a half-dose in cc to achieve effective contraction of the uterus. Meanwhile, the information of patients including systolic and diastolic blood pressure (SBP and DBP), heart rate and amount of bleeding during the operation was recorded in a questionnaire.

Results: In the elective cesarean section group, the average SBP was about 117.10mmHg, average DBP 70.50 mmHg, the amount of bleeding during surgery was 623.63mL, and heart rate was 88.88bpm. In the cesarean section group due to difficulty in labor progress, SBP was 113.5 mmHg, DBP 62.69 mmHg, and bleeding was 573.81mL. In addition, 9 patients in the elective group and 3 patients in the lack of progress group, did not require bolus oxytocin. In the lack of a progress group, 8 patients needed more than 5 doses of oxytocin. In addition, about 10 (12%) of all patients had no side effects, and hypotension.

Conclusion: Given that, the minimum effective dose of oxytocin in the elective cesarean section was 1IU, and in those in labor progress was 1-1.5IU, less oxytocin administration represents lesser side effects. It is recommended that patients who are candidates of cesarean section should be administered 1.5IU of oxytocin in the form of bolus.

Keywords: Caesarean section, oxytocin, cervical dilatation, dystocia, intravenous, dysrhythmia.

Graphical Abstract
Cunningham FG, Leveno KJ, Bloom SL, et al. Obstetricia de Williams: McGraw Hill Brasil 2016.
Vahabi S, Haidari M, Akbari Torkamani S, Gorbani Vaghei A. New assessment of relationship between Apgar score and early neonatal mortality. Minerva Pediatr 2010; 62(3): 249-52.
[PMID: 20467376]
Vahabi S, Abaszadeh A, Yari F, Yousefi N. Postoperative pain, nausea and vomiting among pre- and postmenopausal women undergoing cystocele and rectocele repair surgery. Korean J Anesthesiol 2015; 68(6): 581-5.
[] [PMID: 26634082]
Ghafarzadeh M, Lorzadeh N, Zaman M. Comparison study of the effect of magnesium sulfate therapy in pre eclamptic mothers with vaginal delivery on serum level of magnesium, calcium and Pth of preterm and term newborns. J Perinat Med 2007; 35: S287.
Beiranvand S, Karimi A. Effect of encapsulated Artemisia aucheri. L magnetic nanogel extract on shoulder block in rat. Drug Res (Stuttg) 2018; 68(2): 65-71.
[] [PMID: 28847020]
Martindale W, Parfitt K. Effect of encapsulated Artemisia aucheri. L magnetic nanogel extract on shoulder block in rat. Drug res 2018; 68(2): 65-71.
te West NI, Moore KH. Urinary tract infection in gynaecology and obstetrics. Obstetrics, Gynaecol Reprod Med 2014; 24(11): 321-5.
Moradkhani MR, Karimi A, Negahdari B, Nadri S, Eatemadi A. Drug anesthesia for children undergoing magnetic resonance imaging: A review. Biomed Pharmacother 2017; 88: 1183-7.
Carvalho JC, Balki M, Kingdom J, Windrim R. Oxytocin requirements at elective cesarean delivery: Dose-finding study. Obstet Gynecol 2004; 104(5 Pt 1): 1005-10.
[] [PMID: 15516392]
Winograd RH. Uterine artery embolization for postpartum hemorrhage. Best Pract Res Clin Obstet Gynaecol 2008; 22(6): 1119-32.
[] [PMID: 18790676]
Lorzadeh N, Chavoshi M, Dehnori A. Evaluation of Emergency Peripartum Hysterectomy. Thrombosis Research. Pergamon-Elsevier Science Ltd the Boulevard, Langford Lane: Kidlington 2005.
Burkman RT. Danforths’s obstetrics and gynecology. JAMA 2009; 301(6): 672.
Lorzadeh N, Najafi S, Parsa M, Kasemirad C. Effect of maternal hydration on amniotic fluid index. Ultrasound Obstet Gynecol 2005; 26(4): 370-1.
Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application to Local Anaesthesia (LA). Artif Cells Nanomed Biotechnol 2018; 46(2): 355-60.
[] [PMID: 28395522]
Lorzadeh N, Kazemi Rad S. MomenNasab M, Lorzadeh M, Safa M. The effects of daily fluoxetine in treatment of premenstrual dysphoric disorder. Iranian J Obstetrics. Gynecol Infertility 2006; 9(2): 39-46.
Lorzadeh N, Kazemirad S, Najafi S. P46. 16: The effect of maternal hydration on Amniotic Fluid Index (AFI). Ultrasound Obstet Gynecol 2007; 30(4): 633.
Lorzadeh N, Kazemirad S. P23. 02: The effects of fetal gender on serum HCG and testestron in normotensive and preeclamtic pregnancies. Ultrasound Obstet Gynecol 2009; 34(S1): 267-8.
Lorzadeh N, Kazemirad S. P14. 12: The predictive value of nonstress test in decrease of amniotic fluid volume and fetal movement. Ultrasound Obstet Gynecol 2011; 38(S1): 217.
Hassanzadeh-Kiabi F, Negahdari B. Antinociceptive synergistic interaction between Achillea millefolium and Origanum vulgare L. extract encapsulated in liposome in rat. Artif Cells Nanomed Biotechnol 2018; 46(5): 994-1000.
[] [PMID: 28720004]
Akbariasbagh F, Lorzadeh N, Azmoodeh A, Ghaseminejad A, Mohamadpoor J, Kazemirad S. Association among diameter and volume of follicles, oocyte maturity, and competence in intracytoplasmic sperm injection cycles. Minerva Ginecol 2015; 67(5): 397-403.
[PMID: 26491821]
Lorzadeh N, Sepavand F, Soleimaninezhad M, Kazemirad N. The effect of extract of internal layer of quer-cus (OAK GAL) in contraction of vaginal smooth muscles in women with vaginal relaxation. J Med Plants Res 2016; 15(60): 173-81.
Lorzadeh N, Sepavand F, Soleimaninezhad M, Kazemirad N. The effect of extract of oak gall for vaginal tightening and rejuvenation in women with vaginal relaxation. Open J Obstet Gynecol 2016; 6(13): 879-87.
Lorzadeh N, Ghafarzadeh M, Vahabi S, Lashgarara GR. Pregnancy outcome following M. MR vaccination. YAFTEH 2017; 9(32): 11-5.
Moradkhani MR, Karimi A, Negahdari B. Nanotechnology application for pain therapy. Artif Cells Nanomed Biotechnol 2018; 46(2): 368-73.
[] [PMID: 28395516]
Hassanzadeh-Kiabi F, Razavi S, Moradkhani M, Moemenzadeh S, Neematollahi F. Comparison of pulsed radiofrequency and medial branch blockage in controlling facet-originating low back pain. Anesth Pain Med 2012; 3(3): 39.
Balki M, Ronayne M, Davies S, et al. Minimum oxytocin dose requirement after cesarean delivery for labor arrest. Obstet Gynecol 2006; 107(1): 45-50.
[] [PMID: 16394038]
Beiranvand S, Moradkhani MR. Bupivacaine versus liposomal bupivacaine for pain control. Drug Res (Stuttg) 2018; 68(7): 365-9.
[] [PMID: 29108087]
Moradkhani MR, Karimi A. Role of drug anesthesia and cancer. Drug Res (Stuttg) 2018; 68(3): 125-31.
[] [PMID: 29161749]
Weis FR Jr, Markello R, Mo B, Bochiechio P. Cardiovascular effects of oxytocin. Obstet Gynecol 1975; 46(2): 211-4.
[PMID: 1153152]

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