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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Recent Progress on the Discovery of Sirt2 Inhibitors for the Treatment of Various Cancers

Author(s): Ting Wang, Zhuyu Xu, Yongping Lu, Jianyou Shi, Wenbo Liu, Chengchen Zhang, Zhongliang Jiang, Baowen Qi* and Lan Bai*

Volume 19, Issue 12, 2019

Page: [1051 - 1058] Pages: 8

DOI: 10.2174/1568026619666190510103416

Price: $65


Sirtuins family is a class of NDA+ dependent protein deacetylases that play a key role in the regulation of several aspects of biological processes, such as cell cycle regulation, autophagy, immune and inflammatory response. Many studies have shown that sirtuins2 as a key player in the cancer pathway is of great significance in tumorigenesis. This review summarizes the newly discovered, in recent years, some SIRT2 inhibitors for cancer target structure, action mechanism, biological activity, substrate specificity, and signaling pathways.

Keywords: Sirtuins, Sirt2 inhibitor, Substrate, Signaling pathways, Cancer, N-terminal.

Graphical Abstract
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