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Review Article

金纳米颗粒在癌症治疗中作为靶向递送系统和治疗剂

卷 26, 期 35, 2019

页: [6493 - 6513] 页: 21

弟呕挨: 10.2174/0929867326666190506123721

价格: $65

摘要

癌症仍然是世界范围内主要的死亡原因，而大多数化学疗法会诱发非选择性毒性和严重的全身性副作用。为了解决这些问题，靶向纳米科学是一个有望使癌症患者受益的新兴领域。金纳米颗粒由于其许多公认的优势而成为当今的关注焦点。通过不断发展的一系列方法，包括化学，物理或生态友好的生物方法，可以轻松合成各种形状和大小的金纳米颗粒。这篇综述介绍了金纳米颗粒作为多功能治疗剂，可发挥多种作用，例如靶向递送系统（抗癌剂，核酸，生物蛋白，疫苗），治疗学和光热疗法中的药物。还概述了它们，以在生物成像领域（例如放射治疗，磁共振血管造影和光声成像）中做出巨大贡献。然而，金纳米颗粒是治疗剂，其证明其对多种细胞系，例如人宫颈，人乳腺，人肺，人前列腺和鼠类黑色素瘤癌细胞具有体外抗血管生成，抗增殖和促凋亡作用。体内研究指出了有关金纳米颗粒的生物蓄积性和细胞毒性的数据，但人们强调，大小，剂量，表面电荷，性别，尤其是给药途径是非常重要的变量。

关键词: 金纳米颗粒，靶向递送，治疗治疗，癌症治疗，磁共振血管造影，光声成像。

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