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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Analytical Techniques for Small Molecule Solid Phase Synthesis

Author(s): Jan J. Scicinski, Miles S. Congreve, Corinne Kay and Steven V. Ley

Volume 9 , Issue 23 , 2002

Page: [2103 - 2127] Pages: 25

DOI: 10.2174/0929867023368737

Price: $65

Abstract

Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthesis either by monitoring the resin-bound species directly or by the analysis of small quantities of material cleaved from the support. This review outlines some of the principles of the various techniques for the analysis of intermediates and products obtained from solid-phase chemistry.

Keywords: small molecule solid phase synthesis, solid phase organic chemistry


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