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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Immunopathogenesis of Behçet Disease

Author(s): Israel Gañán Nieto* and José Luis Castañer Alabau

Volume 16 , Issue 1 , 2020

Page: [12 - 20] Pages: 9

DOI: 10.2174/1573397115666190415142426

Price: $65


Background: Behçet’s Disease (BD, OMIM 109650) is a chronic relapsing inflammatory disease of unknown etiology with unpredictable exacerbations and remissions. First described in 1937 by the Turkish dermatologist HulusiBehçet, as a trisympton complex (oral and genital ulcers and uveitis), it is now recognized as a multisystemic disease. The syndrome can manifest in diverse ways and can involve nearly every organ system. Several studies have implicated T cells and monocytes in the pathogenesis of BD especially when these cells are stimulated by heat shock proteins and streptococcal antigen. This article presents a review of the relevant published literature about the immunopathogenesis of BD.

Result: The authors used MeSH terms “Behçet’s disease” with “pathophysiology,” “pathogenesis,” “genetic”, “epigenetic”, “immunogenetic” or “immune response” to search the PubMed database. All the relevant studies identified were included.

Keywords: Behçet's disease, genetics, epigenetics, immunopathogenesis, etiology, pathophysiology.

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