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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Bisphosphonate Prodrugs

Author(s): Jouko J. Vepsalainen

Volume 9 , Issue 12 , 2002

Page: [1201 - 1208] Pages: 8

DOI: 10.2174/0929867023369998

Price: $65


Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).

Keywords: pyrohosphate analogs, bisphosphonate, clodronate, etidronate

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