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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

胃肠道间质瘤的突变检测

卷 19, 期 9, 2019

页: [688 - 697] 页: 10

弟呕挨: 10.2174/1568009619666190326123945

价格: $65

摘要

靶向治疗已成为癌症治疗的主要方式。这样的抗癌药通常被设计用于治疗具有某些遗传/基因组组成的肿瘤。在开具针对性疗法之前进行突变测试对于确定谁可以从特定的癌症药物中获得临床益处至关重要。在过去的二十年中，胃肠道间质瘤（GIST）已从组织学上的模糊发展为具有明确的临床和分子特征的独特的胃肠道间质瘤，为此可采用多种靶向疗法。尽管美国国家综合癌症网络（NCCN）强烈建议采用突变测试以优化GIST的治疗，但许多GIST患者仍未进行突变测试或任何突变指导的癌症治疗。在这里，我们回顾了GIST的突变指导格局，突变测试方法以及针对具有特定突变的GIST的新疗法的最新进展。

关键词: 胃肠道间质瘤，肉瘤，突变检测，KIT，PDGFRA，突变指导的癌症管理。

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