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Review Article

分子伴侣HSP70和细胞凋亡的关键调节因子 - 综述

卷 19, 期 5, 2019

页: [315 - 325] 页: 11

弟呕挨: 10.2174/1566524019666190326114720

价格: $65

摘要

鉴于由于升高的温度变化而组成性地合成的分子伴侣，该热休克蛋白HSP70已显示与许多蛋白质生物发生密切相关，促进蛋白质的合成和折叠以及细胞生长期间新生肽的运输。 HSP70在蛋白质组装，调节和与多种蛋白质的相互作用中也起着至关重要的作用。应激诱导的细胞死亡处于凋亡调节因子Bcl-2家族的控制之下，并显示出促凋亡或抗细胞凋亡活性。受到热应激等应激条件的影响，据报道细胞表达HSP70表达升高。此外，这种分子伴侣已经表明通过修复，重新合成受损蛋白质和稳定未折叠蛋白质，在多个水平上起作用以抑制一些Bcl-2成员的应激诱导的凋亡信号。因此，HSP70合成可以作为致死条件下细胞存活和适应的基本恢复模式。

关键词: 分子伴侣，热休克蛋白，HSP70，细胞凋亡，Bcl-2家族蛋白，caspase。

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