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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Treatments for Iron Deficiency (ID): Prospective Organic Iron Fortification

Author(s): Dan Wan, Qinghua Wu, Hengjia Ni, Gang Liu*, Zheng Ruan* and Yulong Yin

Volume 25 , Issue 3 , 2019

Page: [325 - 332] Pages: 8

DOI: 10.2174/1381612825666190319111437

Price: $65


Iron deficiency, one of the most common nutritional deficient disorders, frequently affects infants, adolescents and pregnant women and impairs growth, development and immune responses. Iron deficiency may also be secondary to gastrointestinal conditions such as gastrectomy and inflammatory bowel disease, as well as cancer and chronic uremia. Iron supplementation is the most commonly selected treatment option for iron deficiency. This review summarizes the iron compounds currently recommended for the iron fortification of foods and for clinical use. Additionally, this review discusses and compares the important aspects of high-quality iron compounds/products and classes of compounds that enhance iron bioavailability. The development of efficient iron fortification methods remains the most cost-effective and long-term approach to the treatment of iron deficiency or related anemia. To date, no orally administered options for iron fortification can sufficiently replace the parenteral administration of iron supplements, which includes the intramuscular injection of iron-dextran to neonatal piglets and intravenous injection of iron supplements to patients with gastrointestinal disorders. Iron bioavailability may be enhanced by encouraging customers to ingest iron-enriched foods together with dietary sources of vitamin C, folic acid and/or oligosaccharides.

Keywords: Iron deficiency, iron supplements, anemia, organic iron, iron fortification, immune responses.

Wan D, Zhang YM, Wu X, et al. Maternal dietary supplementation with ferrous N-carbamylglycinate chelate affects sow reproductive performance and iron status of neonatal piglets. Animal 2018; 12(7): 1372-9.
Mimura ECM, Breganó JW, Dichi JB, Gregório EP, Dichi I. Comparison of ferrous sulfate and ferrous glycinate chelate for the treatment of iron deficiency anemia in gastrectomized patients. Nutrition 2008; 24(7-8): 663-8.
Nakamori M, Hien VTT, Khan NC, et al. Difructose anhydride III enhances bioavailability of water-insoluble iron in anemic Vietnamese women. J Nutr Sci Vitaminol (Tokyo) 2010; 56(3): 191-7.
Ferrari P, Nicolini A, Manca ML, et al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother 2012; 66(6): 414-8.
Wan D, Zhou X, Xie C, Shu X, Wu X, Yin Y. Toxicological evaluation of ferrous N-carbamylglycinate chelate: Acute, Sub-acute toxicity and mutagenicity. Regul Toxicol Pharmacol 2015; 73(2): 644-51.
Thomson CA, Stanaway JD, Neuhouser ML, et al. Nutrient intake and anemia risk in the women’s health initiative observational study. J Am Diet Assoc 2011; 111(4): 532-41.
Kordas K. Iron Lead. Children’s behavior and cognition. Annu Rev Nutr 2010; 30: 123-48.
Bouhouch RR, El-Fadeli S, Andersson M, et al. Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: A double-blind randomized controlled trial. Am J Clin Nutr 2016; 104(5): 1318-26.
Nielsen OH, Ainsworth M, Coskun M, Weiss G. Management of iron-deficiency anemia in inflammatory bowel disease: a systematic review. Medicine (Baltimore) 2015; 94(23): e963.
Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr 1998; 68(2)(2 Suppl.): 442S-6S.
Hemery YM, Laillou A, Fontan L, et al. Storage conditions and packaging greatly affects the stability of fortified wheat flour: Influence on vitamin A, iron, zinc, and oxidation. Food Chem 2018; 240: 43-50.
O’Sullivan MG, Byrne DV, Stagsted J, Andersen HJ, Martens M. Sensory colour assessment of fresh meat from pigs supplemented with iron and vitamin E. Meat Sci 2002; 60(3): 253-65.
Lysionek AE, Zubillaga MB, Salgueiro MJ, et al. Stabilized ferrous gluconate as iron source for food fortification: bioavailability and toxicity studies in rats. Biol Trace Elem Res 2003; 94(1): 73-8.
Walczyk T, Tuntipopipat S, Zeder C, Sirichakwal P, Wasantwisut E, Hurrell RF. Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce. Eur J Clin Nutr 2005; 59(5): 668-74.
Kapsokefalou M, Alexandropoulou I, Komaitis M, Politis I. In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers. Int J Food Sci Nutr 2005; 56(4): 293-302.
Prutki M, Poljak-Blazi M, Mihaljevic B, Orescanin V, Zarkovic N. Uptake of anti-anemic substance ferric-sorbitol-citrate by normal and malignant cells and its effects on expression of transferrin receptor 1 and ferritin. Cancer Biother Radiopharm 2006; 21(6): 636-44.
Chavasit V, Porasuphatana S, Suthutvoravut U, Zeder C, Hurrell R. Iron bioavailability in 8-24-month-old Thai children from a micronutrient-fortified quick-cooking rice containing ferric ammonium citrate or a mixture of ferrous sulphate and ferric sodium ethylenediaminetetraacetic acid. Matern Child Nutr 2015; 11(Suppl. 4): 179-87.
Singh K, Fong YF, Kuperan P. A comparison between intravenous iron polymaltose complex (Ferrum Hausmann) and oral ferrous fumarate in the treatment of iron deficiency anaemia in pregnancy. Eur J Haematol 1998; 60(2): 119-24.
Liu TC, Lin SF, Chang CS, Yang WC, Chen TP. Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia: A Taiwanese study. Int J Hematol 2004; 80(5): 416-20.
Hurrell RF, Furniss DE, Burri J, Whittaker P, Lynch SR, Cook JD. Iron fortification of infant cereals: A proposal for the use of ferrous fumarate or ferrous succinate. Am J Clin Nutr 1989; 49(6): 1274-82.
Hurrell R. Use of ferrous fumarate to fortify foods for infants and young children. Nutr Rev 2010; 68(9): 522-30.
Veum TL, Gallo JT, Pond WG, Vanvleck LD, Loosli JK. Effect of Ferrous Fumarate in Lactation Diet on Sow Milk Iron Pig Hemoglobin and Weight Gain. J Anim Sci 1965; 24: 1169.
Veum TL, Pond WG, Loosli JK, Vanvleck LD, Gallo JT. Effect of Feeding Ferrous Fumarate on Sow Milk Iron + Pig Hemoglobin. J Anim Sci 1964; 23: 896.
Miller ER, Ullrey DE, Zutaut CL, et al. Supplementation of Sow Lactation Diet with Ferrous Fumarate. J Anim Sci 1964; 23: 884.
Andersson M, Thankachan P, Muthayya S, et al. Dual fortification of salt with iodine and iron: A randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India. Am J Clin Nutr 2008; 88(5): 1378-87.
Davidsson L, Kastenmayer P, Szajewska H, Hurrell RF, Barclay D. Iron bioavailability in infants from an infant cereal fortified with ferric pyrophosphate or ferrous fumarate. Am J Clin Nutr 2000; 71(6): 1597-602.
Cao GY, Li KX, Jin PF, Yue XY, Yang C, Hu X. Comparative bioavailability of ferrous succinate tablet formulations without correction for baseline circadian changes in iron concentration in healthy Chinese male subjects: A single-dose, randomized, 2-period crossover study. Clin Ther 2011; 33(12): 2054-9.
Fielding J. Intravenous iron-dextrin in iron-deficiency anaemia. BMJ 1961; 2(5247): 279-83.
Laganà AS, Costabile L, Filati P, Noventa M, Vitagliano A, D’Anna R. Effects of micronised dispersible ferric pyrophosphate combined with alpha-lactalbumin in pregnant women affected by iron deficiency anemia: results from a prospective, double-blind, randomized controlled trial. Eur Rev Med Pharmacol Sci 2018; 22(11): 3602-8.
Teshome EM, Andang’o PEA, Osoti V, et al. Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: A randomised, placebo-controlled, non-inferiority trial in Kenyan children. BMC Med 2017; 15(1): 89.
Bothwell TH, MacPhail AP. The potential role of NaFeEDTA as an iron fortificant. Int J Vitam Nutr Res 2004; 74(6): 421-34.
Allen LH. Advantages and limitations of iron amino acid chelates as iron fortificants. Nutr Rev 2002; 60(7 Pt 2): S18-21.
Stokar-Regenscheit N, Sydler T, Bürgi E, Lippuner A, Naegeli H, Sidler X. Lethal Gastric Mucosal Necrosis due to Administration of Oral Ferrous Bisglycinate Chelate to Suckling Piglets. J Comp Pathol 2017; 157(1): 39-45.
Winiarska-Mieczan A, Kwiecień M, Grela ER, Tomaszewska E, Klebaniuk R. The chemical composition and sensory properties of raw, cooked and grilled thigh meat of broiler chickens fed with Fe-Gly chelate. J Food Sci Technol 2016; 53(10): 3825-33.
Liu AJ, Wang LX, Ma Y, Liu JB, Zhang GR. A new nutrient polypeptide-Fe and its antioxidant ability. Int J Food Sci Nutr 2009; 60(Suppl. 2): 185-96.
Park KH, Kim HS, Han MK, Kim UH. Heme iron polypeptide polymer with high iron content as an ideal iron supplement. J Food Biochem 2010; 34: 896-904.
Nagaraju SP, Cohn A, Akbari A, Davis JL, Zimmerman DL. Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: A randomized controlled trial. BMC Nephrol 2013; 14: 64.
Milanovic S, Lazarevic M, Jokic Z, et al. The influence of organic and inorganic Fe supplementation on red blood picture, immune response and quantity of iron in organs of broiler chickens. Acta Vet (Beogr) 2008; 58: 179-89.
Zhang XG, Wei GX, Wang WN, Ma GD, Tang P, Chen XQ. Effects of Fe-YM1504 on iron deficiency anemia in rats. Food Funct 2016; 7(7): 3184-92.
Shim JY, Kim MY, Kim YJ, et al. Efficacy and safety of ferric carboxymaltose versus ferrous sulfate for iron deficiency anemia during pregnancy: subgroup analysis of Korean women. BMC Pregnancy Childbirth 2018; 18(1): 349.
Ines YG, Monica FM, Esther DG, Belen MA, Alvaro GM, Maria SS. Ferric carboxymaltose: efficacy and safety. Aten Farm 2012; 14: 251-61.
Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: A review of its use in iron-deficiency anaemia. Drugs 2009; 69(6): 739-56.
Pizarro F, Uicich R, Olivares M, et al. Iron absorption of ferric glycinate is controlled by iron stores. Nutr Res 1998; 18: 3-9.
Olivares M, Pizarro F, Pineda O, Name JJ, Hertrampf E, Walter T. Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans. J Nutr 1997; 127(7): 1407-11.
Amaro-Driedger D, Center LA, Etcheverry P, Grusak MA. Assessing Iron Bioavailability from Commercial Supplements Containing Iron. Tex J Sci 2012; 64: 145-54.
Harrington M, Hotz C, Zeder C, et al. A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink. Eur J Clin Nutr 2011; 65(1): 20-5.
Zlotkin S, Arthur P, Antwi KY, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr 2001; 74(6): 791-5.
Davidsson L, Sarker SA, Jamil KA, Sultana S, Hurrell R. Regular consumption of a complementary food fortified with ascorbic acid and ferrous fumarate or ferric pyrophosphate is as useful as ferrous sulfate in maintaining hemoglobin concentrations >105 g/L in young Bangladeshi children. Am J Clin Nutr 2009; 89(6): 1815-20.
Geltman PL, Hironaka LK, Mehta SD, et al. Iron supplementation of low-income infants: A randomized clinical trial of adherence with ferrous fumarate sprinkles versus ferrous sulfate drops. J Pediatr 2009; 154(5): 738-43.
Glinz D, Wegmüller R, Ouattara M, et al. Iron fortified complementary foods containing a mixture of sodium iron EDTA with either ferrous fumarate or ferric pyrophosphate reduce iron deficiency anemia in 12- to 36-month-old children in a malaria endemic setting: A secondary analysis of a cluster-randomized controlled trial. Nutrients 2017; 9(7): 9.
Navas-Carretero S, Sarriá B, Pérez-Granados AM, Schoppen S, Izquierdo-Pulido M, Vaquero MP. A comparative study of iron bioavailability from cocoa supplemented with ferric pyrophosphate or ferrous fumarate in rats. Ann Nutr Metab 2007; 51(3): 204-7.
Herter-Aeberli I, Eliancy K, Rathon Y, Loechl CU, Marhône Pierre J, Zimmermann MB. In Haitian women and preschool children, iron absorption from wheat flour-based meals fortified with sodium iron EDTA is higher than that from meals fortified with ferrous fumarate, and is not affected by Helicobacter pylori infection in children. Br J Nutr 2017; 118(4): 273-9.
Ma WQ, Wu J, Zhuo Z, Sun H, Yue M, Feng J. Comparison of absorption characteristics of iron glycine chelate and ferrous sulfate in caco-2 cells. Int J Agric Biol 2013; 15: 372-6.
Rojas ML, Sánchez J, Villada Ó, et al. Effectiveness of iron amino acid chelate versus ferrous sulfate as part of a food complement in preschool children with iron deficiency, Medellín, 2011. Biomedica 2013; 33(3): 350-60.
Abdel Moety GAF, Ali AM, Fouad R, Ramadan W, Belal DS, Haggag HM. Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. Eur J Obstet Gynecol Reprod Biol 2017; 210: 242-6.
Duque X, Martinez H, Vilchis-Gil J, et al. Effect of supplementation with ferrous sulfate or iron bis-glycinate chelate on ferritin concentration in Mexican schoolchildren: A randomized controlled trial. Nutr J 2014; 13: 71.
Kapsokefalou M, Kakouris V, Makris K, Galiotou-Panayotou M, Komaitis M. Oxidative activity and dialyzability of some iron compounds under conditions of a simulated gastrointestinal digestion in the presence of phytate. Food Chem 2007; 101: 419-27.
Haro-Vicente JF, Perez-Conesa D, Braquehais FR, Ros G. Iron absorption and haemoglobin status of rats fed a ferrous bisglycinate-fortified growing-up milk. J Sci Food Agric 2009; 89: 2107-14.
Zimmermann MB, Biebinger R, Egli I, Zeder C, Hurrell RF. Iron deficiency up-regulates iron absorption from ferrous sulphate but not ferric pyrophosphate and consequently food fortification with ferrous sulphate has relatively greater efficacy in iron-deficient individuals. Br J Nutr 2011; 105(8): 1245-50.
García-Casal MN, Layrisse M. The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds. Arch Latinoam Nutr 2001; 51(1)(Suppl. 1): 35-6.
Swietlik R, Trojanowska M, Debska P. Modeling the Chemical Speciation of Iron Released from Commercially Available Oral Iron Supplements and Iron Food Fortificants. J Elem 2018; 23: 999-1007.
Cercamondi CI, Duchateau GSMJE, Harika RK, et al. Sodium pyrophosphate enhances iron bioavailability from bouillon cubes fortified with ferric pyrophosphate. Br J Nutr 2016; 116(3): 496-503.
Christofides A, Asante KP, Schauer C, Sharieff W, Owusu-Agyei S, Zlotkin S. Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: A randomized clinical trial. Matern Child Nutr 2006; 2(3): 169-80.
Jover R, Ponsoda X, Castell JV, Gómez-Lechón MJ. Evaluation of the cytotoxicity of ten chemicals on human cultured hepatocytes: Predictability of human toxicity and comparison with rodent cell culture systems. Toxicol In Vitro 1992; 6(1): 47-52.
Boccio JR, Zubillaga MB, Caro RA, et al. Bioavailability, absorption mechanism, and toxicity of microencapsulated iron (I) sulfate: studies in mice. Biol Trace Elem Res 1998; 62(1-2): 65-73.
Whittaker P, Ali SF, Imam SZ, Dunkel VC. Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. Regul Toxicol Pharmacol 2002; 36(3): 280-6.
Toblli JE, Cao G, Olivieri L, Angerosa M. Comparative study of gastrointestinal tract and liver toxicity of ferrous sulfate, iron amino chelate and iron polymaltose complex in normal rats. Pharmacology 2008; 82(2): 127-37.
Li YJ, Lin HM, Deng SG, Zhang HQ, Shi YJ. Genotoxicity and acute oral toxicity of peptides ferrous chelates of Hairtail protein. Int J Clin Exp Med 2016; 9: 4047-52.
Kolacz R, Bodak E, Dolinska B, Dobrzanski Z, Ryszka F. Iron parameters in the blood serum of suckling pigs after oral treatment with ferrous fumarate. Med Weter 2001; 57: 680-6.
Joseph B, Ramesh N. Weekly dose of Iron-Folate Supplementation with Vitamin-C in the workplace can prevent anaemia in women employees. Pak J Med Sci 2013; 29(1): 47-52.
Haro-Vicente JF, Pérez-Conesa D, Rincón F, Ros G, Martínez-Graciá C, Vidal ML. Does ascorbic acid supplementation affect iron bioavailability in rats fed micronized dispersible ferric pyrophosphate fortified fruit juice? Eur J Nutr 2008; 47(8): 470-8.
García-Casal MN, Leets I. Carotenoids, but not vitamin A, improve iron uptake and ferritin synthesis by Caco-2 cells from ferrous fumarate and NaFe-EDTA. J Food Sci 2014; 79(4): H706-12.
Lobo AR, Gaievski EHS, De Carli E, Alvares EP, Colli C. Fructo-oligosaccharides and iron bioavailability in anaemic rats: the effects on iron species distribution, ferroportin-1 expression, crypt bifurcation and crypt cell proliferation in the caecum. Br J Nutr 2014; 112(8): 1286-95.
Paganini D, Uyoga MA, Cercamondi CI, et al. Consumption of galacto-oligosaccharides increases iron absorption from a micronutrient powder containing ferrous fumarate and sodium iron EDTA: A stable-isotope study in Kenyan infants. Am J Clin Nutr 2017; 106(4): 1020-31.
Gunn C, Islip MC, Masters PL, Erskine-Murray H, Rigg CA, Stapelton T. Iron-deficiency anaemia between 3 months and 2 years of age and a comparison of treatment with ferrous sulphate and ferrous fumarate. Arch Dis Child 1960; 35: 281-4.
Leger CS, Ooi TC. Ferrous fumarate-induced malabsorption of thyroxine. Endocrinologist 1999; 9: 493-5.
Fudin R, Jaichenko J, Shostak A, Bennett M, Gotloib L. Correction of uremic iron deficiency anemia in hemodialyzed patients: A prospective study. Nephron 1998; 79(3): 299-305.
Santarpia L, Pagano MC, Cuomo R, Alfonsi L, Contaldo F, Pasanisi F. Iron absorption following a single oral dose of ferrous sulfate or ferric gluconate in patients with gastrectomy. Ann Nutr Metab 2013; 63(1-2): 55-9.
Ahmadzadeh S, Dolatabadi M. Electrochemical treatment of pharmaceutical wastewater through electrosynthesis of iron hydroxides for practical removal of metronidazole. Chemosphere 2018; 212: 533-9.
El-Boubbou K. Magnetic iron oxide nanoparticles as drug carriers: clinical relevance. Nanomedicine (Lond) 2018; 13(8): 953-71.
Navas-Carretero S, Perez-Granados AM, Sarria B, Schoppen S, Vaquero MP. Iron Bioavailability from pate enriched with encapsulated ferric pyrophosphate or ferrous gluconate in rats. Food Sci Technol Int 2007; 13: 159-63.
Huang Y, Lin D, Taniguchi CM. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Sci China Life Sci 2017; 60(10): 1114-24.
Sakaguchi N, Rao TP, Nakata K, Nanbu H, Juneja LR. Iron absorption and bioavailability in rats of micronized dispersible ferric pyrophosphate. Int J Vitam Nutr Res 2004; 74(1): 3-9.
Osman AK, al-Othaimeen A. Experience with ferrous bis-glycine chelate as an iron fortificant in milk. Int J Vitam Nutr Res 2002; 72(4): 257-63.
Ding BM, Zhang XM, Hayat K, et al. Preparation, characterization and the stability of ferrous glycinate nanoliposomes. J Food Eng 2011; 102: 202-8.
Szarfarc SC, de Cassana LMN, Fujimori E, Guerra-Shinohara EM, de Oliveira IMV. Relative effectiveness of iron bis-glycinate chelate (Ferrochel) and ferrous sulfate in the control of iron deficiency in pregnant women. Arch Latinoam Nutr 2001; 51(Suppl. 1): 42-7.
Salgueiro MJ, Zubillaga M, Lysionek A, Caro R, Weill R, Boccio J. Fortification strategies to combat zinc and iron deficiency. Nutr Rev 2002; 60(2): 52-8.
Zhuo Z, Fang S, Yue M, Zhang Y, Feng J. Kinetics absorption characteristics of ferrous glycinate in SD rats and its impact on the relevant transport protein. Biol Trace Elem Res 2014; 158(2): 197-202.
Milman N, Jønsson L, Dyre P, Pedersen PL, Larsen LG. Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial. J Perinat Med 2014; 42(2): 197-206.
Feng J, Ma WQ, Xu ZR, Wang YZ, Liu JX. Effects of iron glycine chelate on growth, haematological and immunological characteristics in weanling pigs. Anim Feed Sci Technol 2007; 134: 261-72.
Hameed S, Bhattarai P, Dai Z. Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment. Sci China Life Sci 2018; 61(4): 380-91.
Ren L, Gao X, Yang C, et al. Comparison of diploid and triploid Carassius auratus provides insights into adaptation to environmental change. Sci China Life Sci 2018; 61(11): 1407-19.
Wang M, Bao L, Qiu X, et al. Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization. Sci China Life Sci 2018; 61(10): 1168-77.
Yeung CK, Glahn RP, Miller DD. Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells. J Agric Food Chem 2005; 53(1): 132-6.
Li S, Sun X, Ma X. Effects of Cyclic Tensile Strain on Oxidative Stress and the Function of Schwann Cells. BioMed Res Int 2018; 2018: 5746525.
Zhu D, Ma Y, Ding S, Jiang H, Fang J. Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. BioMed Res Int 2018; 2018: 2607679.
Zhuo Z, Fang S, Hu Q, Huang D, Feng J. Digital gene expression profiling analysis of duodenum transcriptomes in SD rats administered ferrous sulfate or ferrous glycine chelate by gavage. Sci Rep 2016; 6: 37923.
Ding BM, Yi XZ, Li L, Yang HL. Assessment of ferrous glycinate liposome absorption using in situ single-pass perfusion model. Int J Food Eng 2017; 20160385.
Baomiao D, Xiangzhou Y, Li L, Hualin Y. Evaluation of iron transport from ferrous glycinate liposomes using Caco-2 cell model. Afr Health Sci 2017; 17(3): 933-41.
Thuy PV, Berger J, Davidsson L, et al. Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women. Am J Clin Nutr 2003; 78(2): 284-90.
Kloots W, Op den Kamp D, Abrahamse L. In vitro iron availability from iron-fortified whole-grain wheat flour. J Agric Food Chem 2004; 52(26): 8132-6.
Troesch B, Egli I, Zeder C, Hurrell RF, Zimmermann MB. Fortification iron as ferrous sulfate plus ascorbic acid is more rapidly absorbed than as sodium iron EDTA but neither increases serum nontransferrin-bound iron in women. J Nutr 2011; 141(5): 822-7.
Lopez Barrera EC, Gaur S, Andrade JE, Engeseth NJ, Nielsen C, Helferich WG. Iron Fortification of Spiced Vinegar in the Philippines. J Food Sci 2018; 83(10): 2602-11.
Barth-Jaeggi T, Moretti D, Kvalsvig J, et al. In-home fortification with 2.5 mg iron as NaFeEDTA does not reduce anaemia but increases weight gain: A randomised controlled trial in Kenyan infants. Matern Child Nutr 2015; 11(Suppl. 4): 151-62.
Kim HS, Kim MK, Lee BK. Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. Nutrition 2009; 25(1): 66-71.
Navas-Carretero S, Pérez-Granados AM, Sarriá B, Vaquero MP. Iron absorption from meat pate fortified with ferric pyrophosphate in iron-deficient women. Nutrition 2009; 25(1): 20-4.
Roe MA, Collings R, Hoogewerff J, Fairweather-Tait SJ. Relative bioavailability of micronized, dispersible ferric pyrophosphate added to an apple juice drink. Eur J Nutr 2009; 48(2): 115-9.
Giunta G, Giuffrida L, Mangano K, Fagone P, Cianci A. Influence of lactoferrin in preventing preterm delivery: A pilot study. Mol Med Rep 2012; 5(1): 162-6.
Pratt R, Handelman GJ, Edwards TE, Gupta A. Ferric pyrophosphate citrate: interactions with transferrin. Biometals 2018; 31(6): 1081-9.
Pratt R, Gupta A. Ferric Pyrophosphate Citrate (Triferic (R)), a novel therapy that treats anemia of inflammation and overcomes functional iron deficiency. Am J Hematol 2017; 92: E230.
Xiao C, Lei X, Wang Q, et al. Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats. Biol Trace Elem Res 2016; 169(2): 211-7.
Zhu C, Yang F, Fan D, Wang Y, Yu Y. Higher iron bioavailability of a human-like collagen iron complex. J Biomater Appl 2017; 32(1): 82-92.
Caetano-Silva ME, Cilla A, Bertoldo-Pacheco MT, Netto FM, Alegria A. Evaluation of in vitro iron bioavailability in free form and as whey peptide-iron complexes. J Food Compos Anal 2018; 68: 95-100.

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