Background: Many neurological disorders lead to institutionalization and can be accompanied in their advanced stages by functional impairment, and progressive loss of mobility, and cognitive alterations.
Objective: We analyzed the relationship between functional impairment and cognitive performance and its related subdomains in individuals with Parkinson’s disease, Alzheimer’s disease accompanied by motor dysfunction, and with other neurological disorders characterized by both motor and cognitive problems.
Methods: All participants lived in nursing homes (Valencia, Spain) and underwent cognitive evaluation with the Mini-Mental State Examination; functional assessment of independence in activities of daily living using the Barthel score and Katz index; and assessment of mobility with the elderly mobility scale.
Results: The mean age of the subjects was 82.8 ± 0.6 years, 47% of the sample included individuals with Parkinson’s disease, and 48 % of the sample presented severe cognitive impairment. Direct significant relationships were found between the level of cognitive impairment and functional capacity (p < 0.01) and mobility (p < 0.05). Among the different domains, memory impairment was not associated with altered activities of daily living or mobility. The functional impairment and the risk of severe cognitive impairment were significantly (p<0.05) higher in female compared to male patients. Among comorbidities, overweight/obesity and diabetes were significantly (p < 0.05) associated with poor cognitive performance in those individuals with mild/moderate cognitive impairment.
Conclusion: In institutionalized individuals with movement disorders there is an association between functional and cognitive impairment. Reduction of over-weight and proper control of diabetes may represent novel targets for improving cognitive function at such early stages.
[http://dx.doi.org/10.1002/mds.23823] [PMID: 21661055]
[http://dx.doi.org/10.1111/j.1532-5415.1999.tb07240.x] [PMID: 10203123]
[http://dx.doi.org/10.1186/s12877-016-0328-9] [PMID: 27549203]
[http://dx.doi.org/10.2174/1745017901713010181] [PMID: 29238394]
[http://dx.doi.org/10.1016/0165-1781(92)90005-N] [PMID: 1594710]
[http://dx.doi.org/10.1016/j.ejim.2014.06.027] [PMID: 25051903]
[http://dx.doi.org/10.1093/gerona/glp130] [PMID: 19723771]
[http://dx.doi.org/10.3233/JAD-150154] [PMID: 26402085]
[http://dx.doi.org/10.1016/j.jpsychires.2018.04.016] [PMID: 29729620]
[http://dx.doi.org/10.1097/00002093-200001000-00001] [PMID: 10718199]
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.08.019] [PMID: 16223549]
[http://dx.doi.org/10.1212/01.wnl.0000238082.13860.50] [PMID: 17030754]
[http://dx.doi.org/10.1523/JNEUROSCI.2266-11.2011] [PMID: 21832188]
[http://dx.doi.org/10.1111/j.1749-6632.2010.05726.x] [PMID: 20955439]
[http://dx.doi.org/10.1007/s11695-013-0970-7] [PMID: 23636994]
[http://dx.doi.org/10.2174/1872214810999160628105549] [PMID: 27396477]