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Current Protein & Peptide Science


ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Isoleucine Plays an Important Role for Maintaining Immune Function

Author(s): Changsong Gu, Xiangbing Mao*, Daiwen Chen, Bing Yu and Qing Yang

Volume 20 , Issue 7 , 2019

Page: [644 - 651] Pages: 8

DOI: 10.2174/1389203720666190305163135

Price: $65


Branched chain amino acids are the essential nutrients for humans and many animals. As functional amino acids, they play important roles in physiological functions, including immune functions. Isoleucine, as one of the branched chain amino acids, is also critical in physiological functions of the whole body, such as growth, immunity, protein metabolism, fatty acid metabolism and glucose transportation. Isoleucine can improve the immune system, including immune organs, cells and reactive substances. Recent studies have also shown that isoleucine may induce the expression of host defense peptides (i.e., β-defensins) that can regulate host innate and adaptive immunity. In addition, isoleucine administration can restore the effect of some pathogens on the health of humans and animals via increasing the expression of β-defensins. Therefore, the present review will emphatically discuss the effect of isoleucine on immunity while summarizing the relationship between branched chain amino acids and immune functions.

Keywords: Isoleucine, branched chain amino acids, immune system, β-defensins, TLR/NF-κB pathway, ERK pathway.

Graphical Abstract
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