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Current Bioinformatics


ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

Research Article

Predicting Drug-target Interactions via FM-DNN Learning

Author(s): Jihong Wang, Hao Wang, Xiaodan Wang and Huiyou Chang*

Volume 15, Issue 1, 2020

Page: [68 - 76] Pages: 9

DOI: 10.2174/1574893614666190227160538

Price: $65


Background: Identifying Drug-Target Interactions (DTIs) is a major challenge for current drug discovery and drug repositioning. Compared to traditional experimental approaches, in silico methods are fast and inexpensive. With the increase in open-access experimental data, numerous computational methods have been applied to predict DTIs.

Methods: In this study, we propose an end-to-end learning model of Factorization Machine and Deep Neural Network (FM-DNN), which emphasizes both low-order (first or second order) and high-order (higher than second order) feature interactions without any feature engineering other than raw features. This approach combines the power of FM and DNN learning for feature learning in a new neural network architecture.

Results: The experimental DTI basic features include drug characteristics (609), target characteristics (1819), plus drug ID, target ID, total 2430. We compare 8 models such as SVM, GBDT, WIDE-DEEP etc, the FM-DNN algorithm model obtains the best results of AUC(0.8866) and AUPR(0.8281).

Conclusion: Feature engineering is a job that requires expert knowledge, it is often difficult and time-consuming to achieve good results. FM-DNN can auto learn a lower-order expression by FM and a high-order expression by DNN.FM-DNN model has outstanding advantages over other commonly used models.

Keywords: Drug-target interactions, prediction, factorization machines, DNN learning, machine learning, drug bank.

Graphical Abstract
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