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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

Trigger, Signaling Mechanism and End Effector of Cardioprotective Effect of Remote Postconditioning of Heart

Author(s): Leonid N. Maslov*, Sergey Y. Tsibulnikov, Ekaterina S. Prokudina, Sergey V. Popov, Alla A. Boshchenko, Nirmal Singh, Yi Zhang and Peter R. Oeltgen

Volume 15, Issue 3, 2019

Page: [177 - 187] Pages: 11

DOI: 10.2174/1573403X15666190226095820

Price: $65


The hypothetical trigger of remote postconditioning (RPost) of the heart is the highmolecular weight hydrophobic peptide(s). Nitric oxide and adenosine serve as intermediaries between the peptide and intracellular structures. The role of the autonomic nervous system in RPost requires further study. In signaling mechanism RPost, kinases are involved: protein kinase C, PI3, Akt, JAK. The hypothetical end effector of RPost is aldehyde dehydrogenase-2, the transcription factors STAT, Nrf2, and also the BKCa channel.

Keywords: Heart, ischemia, reperfusion, remote postconditioning, humoral factor, autonomic nervous system, signaling, end effector.

Graphical Abstract
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