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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology

Author(s): Xiaoyun Li, Seyed M. Moosavi-Basri, Rahul Sheth, Xiaoying Wang* and Yu S. Zhang*

Volume 24, Issue 45, 2018

Page: [5367 - 5374] Pages: 8

DOI: 10.2174/1381612824666180416114325

Price: $65

Abstract

The role of endovascular interventions has progressed rapidly over the past several decades. While animal models have long-served as the mainstay for the advancement of this field, the use of in vitro models has become increasingly widely adopted with recent advances in engineering technologies. Here, we review the strategies, mainly including bioprinting and microfabrication, which allow for fabrication of biomimetic vascular models that will potentially serve to supplement the conventional animal models for convenient investigations of endovascular interventions. Besides normal blood vessels, those in diseased states, such as thrombosis, may also be modeled by integrating cues that simulate the microenvironment of vascular disorders. These novel engineering strategies for the development of biomimetic in vitro vascular structures will possibly enable unconventional means of studying complex endovascular intervention problems that are otherwise hard to address using existing models.

Keywords: Interventional radiology, bioprinting, soft lithography, tissue engineering, blood vessels, vascular disorders.

[1]
Watson L, Broderick C, Armon MP. Thrombolysis for acute deep vein thrombosis. Cochrane Database Syst Rev 2016; 11: CD002783.
[2]
Hui FK, Fiorella D, Masaryk TJ, Rasmussen PA, Dion JE. A history of detachable coils: 1987-2012. J Neurointerv Surg 2014; 6(2): 134-8.
[3]
Sheth RA, Feldman AS, Paul E, Thiele EA, Walker TG. Sporadic versus Tuberous Sclerosis Complex-Associated Angiomyolipomas: Predictors for Long-Term Outcomes following Transcatheter Embolization. J Vasc Interv Radiol 2016; 27(10): 1542-9.
[4]
Fahed R, Raymond J, Ducroux C, et al. Testing flow diversion in animal models: a systematic review. Neuroradiology 2016; 58(4): 375-82.
[5]
Raj JA, Stoodley M. Experimental Animal Models of Arteriovenous Malformation: A Review. Vet Sci 2015; 2(2): 97-110.
[6]
Lysgaard Poulsen J, Stubbe J, Lindholt JS. Animal Models Used to Explore Abdominal Aortic Aneurysms: A Systematic Review. Eur J Vasc Endovasc Surg 2016; 52(4): 487-99.
[7]
Dick R. Radiology now. Therapeutic angiographic embolization. Br J Radiol 1977; 50(592): 241-2.
[8]
Lubarsky M, Ray CE, Funaki B. Embolization agents-which one should be used when? Part 1: large-vessel embolization. Semin Intervent Radiol 2009; 26(4): 352-7.
[9]
Lubarsky M, Ray C, Funaki B. Embolization agents-which one should be used when? Part 2: small-vessel embolization. Semin Intervent Radiol 2010; 27(1): 99-104.
[10]
Gailloud P, Muster M, Piotin M, et al. In vitro models of intracranial arteriovenous fistulas for the evaluation of new endovascular treatment materials. AJNR Am J Neuroradiol 1999; 20(2): 291-5.
[11]
Sheth R, Balesh ER, Zhang YS, Hirsch JA, Khademhosseini A, Oklu R. Three-Dimensional Printing: An Enabling Technology for IR. J Vasc Interv Radiol 2016; 27(6): 859-65.
[12]
Zhang YS, Duchamp M, Oklu R, Ellisen LW, Langer R, Khademhosseini A. Bioprinting the Cancer Microenvironment. ACS Biomater Sci Eng 2016; 2(10): 1710-21.
[13]
Zhang YS, Yue K, Aleman J, et al. 3D Bioprinting for Tissue and Organ Fabrication. Ann Biomed Eng 2017; 45(1): 148-63.
[14]
Malda J, Visser J, Melchels FP, et al. 25th anniversary article: Engineering hydrogels for biofabrication. Adv Mater 2013; 25(36): 5011-28.
[15]
Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol 2014; 32(8): 773-85.
[16]
Li Y-C, Zhang YS, Akpek A, Shin SR, Khademhosseini A. 4D bioprinting: the next-generation technology for biofabrication enabled by stimuli-responsive materials. Biofabrication 2016; 9(1): 012001.
[17]
Boland T, Mironov V, Gutowska A, Roth EA, Markwald RR. Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. Anat Rec A Discov Mol Cell Evol Biol 2003; 272(2): 497-502.
[18]
Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 2003; 21(4): 157-61.
[19]
Wilson WC Jr, Boland T. Cell and organ printing 1: protein and cell printers. Anat Rec A Discov Mol Cell Evol Biol 2003; 272(2): 491-6.
[20]
Xu T, Jin J, Gregory C, Hickman JJ, Boland T. Inkjet printing of viable mammalian cells. Biomaterials 2005; 26(1): 93-9.
[21]
Boland T, Xu T, Damon B, Cui X. Application of inkjet printing to tissue engineering. Biotechnol J 2006; 1(9): 910-7.
[22]
Cui X, Boland T, D’Lima DD, Lotz MK. Thermal inkjet printing in tissue engineering and regenerative medicine. Recent Pat Drug Deliv Formul 2012; 6(2): 149-55.
[23]
Kang H-W, Lee SJ, Ko IK, Kengla C, Yoo JJ, Atala A. A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nat Biotechnol 2016; 34(3): 312-9.
[24]
Ma X, Qu X, Zhu W, et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci USA 2016; 113(8): 2206-11.
[25]
Franco J, Hunger P, Launey ME, Tomsia AP, Saiz E. Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel. Acta Biomater 2010; 6(1): 218-28.
[26]
Hansen CJ, Saksena R, Kolesky DB, et al. High-throughput printing via microvascular multinozzle arrays. Adv Mater 2013; 25(1): 96-102.
[27]
Khalil S, Nam J, Sun W. Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. Rapid Prototyping J 2005; 11(1): 9-17.
[28]
Khalil S, Sun W. Biopolymer deposition for freeform fabrication of hydrogel tissue constructs. Mater Sci Eng C 2007; 27(3): 469-78.
[29]
Chang R, Nam J, Sun W. Effects of dispensing pressure and nozzle diameter on cell survival from solid freeform fabrication-based direct cell writing. Tissue Eng Part A 2008; 14(1): 41-8.
[30]
Zhao Y, Yao R, Ouyang L, et al. Three-dimensional printing of Hela cells for cervical tumor model in vitro. Biofabrication 2014; 6(3): 035001.
[31]
Ouyang L, Yao R, Mao S, Chen X, Na J, Sun W. Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation. Biofabrication 2015; 7(4): 044101.
[32]
Prendergast ME, Montoya G, Pereira T, Lewicki J, Solorzano R, Atala A. Microphysiological Systems: automated fabrication via extrusion bioprinting Microphysio Syst 2018; 2(3)
[33]
Barron JA, Wu P, Ladouceur HD, Ringeisen BR. Biological laser printing: a novel technique for creating heterogeneous 3-dimensional cell patterns. Biomed Microdevices 2004; 6(2): 139-47.
[34]
Guillotin B, Souquet A, Catros S, et al. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials 2010; 31(28): 7250-6.
[35]
Ali M, Pages E, Ducom A, Fontaine A, Guillemot F. Controlling laser-induced jet formation for bioprinting mesenchymal stem cells with high viability and high resolution. Biofabrication 2014; 6(4): 045001.
[36]
Hull CW. Apparatus for production of three-dimensional objects by stereolithography. US Patents 4575330 1986.
[37]
Lin H, Zhang D, Alexander PG, et al. Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials 2013; 34(2): 331-9.
[38]
Skoog SA, Goering PL, Narayan RJ. Stereolithography in tissue engineering. J Mater Sci Mater Med 2014; 25(3): 845-56.
[39]
Lu Y, Mapili G, Suhali G, Chen S, Roy K. A digital micro-mirror device-based system for the microfabrication of complex, spatially patterned tissue engineering scaffolds. J Biomed Mater Res A 2006; 77(2): 396-405.
[40]
Gauvin R, Chen Y-C, Lee JW, et al. Microfabrication of complex porous tissue engineering scaffolds using 3D projection stereolithography. Biomaterials 2012; 33(15): 3824-34.
[41]
Soman P, Chung PH, Zhang AP, Chen S. Digital microfabrication of user-defined 3D microstructures in cell-laden hydrogels. Biotechnol Bioeng 2013; 110(11): 3038-47.
[42]
Gou M, Qu X, Zhu W, et al. Bio-inspired detoxification using 3D-printed hydrogel nanocomposites. Nat Commun 2014; 5: 3774.
[43]
Huang TQ, Qu X, Liu J, Chen S. 3D printing of biomimetic microstructures for cancer cell migration. Biomed Microdevices 2014; 16(1): 127-32.
[44]
Liu J, Hwang HH, Wang P, Whang G, Chen S. Direct 3D-printing of cell-laden constructs in microfluidic architectures. Lab Chip 2016; 16(8): 1430-8.
[45]
Zhang YS, Oklu R, Dokmeci MR, Khademhosseini A. Three-dimensional bioprinting strategies for tissue engineering. Cold Spring Harb Perspect Med 2018; 8(2): a025718.
[46]
Liu W, Zhang YS, Heinrich MA, et al. Rapid Continuous Multimaterial Extrusion Bioprinting. Adv Mater 2017; 29(3): 1604630.
[47]
Miller JS, Stevens KR, Yang MT, et al. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater 2012; 11(9): 768-74.
[48]
Kolesky DB, Truby RL, Gladman AS, Busbee TA, Homan KA, Lewis JA. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater 2014; 26(19): 3124-30.
[49]
Kolesky DB, Homan KA, Skylar-Scott MA, Lewis JA. Three-dimensional bioprinting of thick vascularized tissues. Proc Natl Acad Sci USA 2016; 113(12): 3179-84.
[50]
Lee VK, Kim DY, Ngo H, et al. Creating perfused functional vascular channels using 3D bio-printing technology. Biomaterials 2014; 35(28): 8092-102.
[51]
Bertassoni LE, Cecconi M, Manoharan V, et al. Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab Chip 2014; 14(13): 2202-11.
[52]
Jia W, Gungor-Ozkerim PS, Zhang YS, et al. Direct 3D bioprinting of perfusable vascular constructs using a blend bioink. Biomaterials 2016; 106: 58-68.
[53]
Pi Q, Maharjan S, Yan X, et al. Digitally Tunable Microfluidic Bioprinting of Multilayered Cannular Tissues. Adv Mater 2018; 30(43): e1706913.
[54]
Zhang W, Zhang YS, Bakht SM, et al. Elastomeric free-form blood vessels for interconnecting organs on chip systems. Lab Chip 2016; 16(9): 1579-86.
[55]
Hou X, Zhang YS. Interplay between materials and microfluidics. Nat Rev Mater 2017; 2(5): 17016.
[56]
Lima R. 2007.
[57]
Wang G-J, Ho K-H, Hsu S-H, Wang K-P. Microvessel scaffold with circular microchannels by photoresist melting. Biomed Microdevices 2007; 9(5): 657-63.
[58]
Lima R, Oliveira MS, Ishikawa T, et al. Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies. Biofabrication 2009; 1(3): 035005.
[59]
Avery RK, Albadawi H, Akbari M, et al. An injectable shear-thinning biomaterial for endovascular embolization. Sci Transl Med 2016; 8(365): 365ra156.
[60]
Zhang YS, Davoudi F, Walch P, et al. Bioprinted thrombosis-on-a-chip. Lab Chip 2016; 16(21): 4097-105.
[61]
Jain A, Graveline A, Waterhouse A, Vernet A, Flaumenhaft R, Ingber DE. A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nat Commun 2016; 7: 10176.
[62]
Lee WG, Ortmann D, Hancock MJ, Bae H, Khademhosseini A. A hollow sphere soft lithography approach for long-term hanging drop methods. Tissue Eng Part C 2009; 16(2): 249-59.
[63]
Chuter TA, Reilly LM, Faruqi RM, et al. Endovascular aneurysm repair in high-risk patients. J Vasc Surg 2000; 31(1 Pt 1): 122-33.
[64]
Sun T, Zhang YS, Pang B, Hyun DC, Yang M, Xia Y. Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl 2014; 53(46): 12320-64.
[65]
Torchilin V. Tumor delivery of macromolecular drugs based on the EPR effect. Adv Drug Deliv Rev 2011; 63(3): 131-5.
[66]
Zervantonakis IK, Hughes-Alford SK, Charest JL, Condeelis JS, Gertler FB, Kamm RD. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci USA 2012; 109(34): 13515-20.
[67]
Jeon JS, Zervantonakis IK, Chung S, Kamm RD, Charest JL. In vitro model of tumor cell extravasation. PLoS One 2013; 8(2): e56910.
[68]
Jeon JS, Bersini S, Gilardi M, et al. Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. Proc Natl Acad Sci USA 2015; 112(1): 214-9.
[69]
Lee VK, Dai G, Zou H, Yoo S-S. Generation of 3-D glioblastomavascular niche using 3-D bioprinting. Biomedical Engineering Conference (NEBEC) 2015.2015 Apr 17-19; Troy, USA.2015.

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