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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Effect of Alpha-FMH and DPPE on Colony-forming Properties of Human Peripheral Progenitor Cells

Author(s): G. Veszely, J. Furesz, E. Pallinger, B. Horkay and A. Falus

Volume 9 , Issue 14 , 2002

Page: [1349 - 1357] Pages: 9

DOI: 10.2174/0929867023369899

Price: $65


Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. The effect of histidine decarboxylase inhibitor (α-fluoromethyl histidine) and the intracellular antagonist of histamine [NN-diethyl-2-4-(phenylmethyl) phenoxyethan-amine-HCl] was investigated on the colonyforming ability of human peripheral progenitor cells. Semi-solid culture medium was used both in the presence and in the absence of 3 U / ml erythropoietin. α-Fluoromethyl histidine was used in the range of 50 through 150 μ Mol / ml, the concentration of NN-diethyl- 2-4-(phenylmethyl) phenoxyethanamine-HCl was between 5 and 25 μ Mol / ml. The number of both the erythroide and the granulocyte macrophage colony was significantly decreased in a concentration dependent manner by the presence of both NN-diethyl-2-4-(phenylmethyl) phenoxyethanamine-HCl (in all concentrations used) and α-fluoromethyl histidine (at higher concentration). The inhibitory effect was decreased by erythropoietin.

Keywords: alpha-fmh, dppe, cfu-gm, peripheral progenitor cell, bfu-e

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