Background: Cancer is an extremely fast, unrestrained and pathological propagation of cells. Yet there is no cancer treatment that is 100% efficient against scattered cancer. Heterocycles have been considered as a boon to treat several cancers of which pyrimidine is a core nucleus and holds an important place in cancer chemotherapy which is reflected in the use of drugs such as 5-fluorouracil, erlotinib, gefitinib and caneratinib. Also, many good antitumor active agents possess benzimidazoleas its core nucleus.
Objective: To design novel pyrimidine-linked benzimidazoles and to explore their structural requirements related to anticancer potential.
Methods: 2D and 3D Quantitative structure–activity relationship (QSAR) studies were carried out on a series of already synthesized 27 pyrimidine-benzimidazole derivatives.
Results: Statistically significant and optimum 2D-QSAR model was developed by using step-wise variable multiple linear regression method, yielding correlation coefficient r2 = 0.89, cross-validated squared correlation coefficient q2 = 0.79 and external predictive ability of pred_r2 = 0.73 Best 3D-QSAR model was developed by employing molecular field analysis using step-wise variable k-nearest neighbor method which showed good correlative and predictive abilities in terms of q2 =0.77 and pred_r2= 0.93.
Conclusion: These 2D and 3D models were found to give dependable indications which helped to optimize the pyrimidine-benzimidazole derivatives of the data set. The data yielded by 2D- QSAR and 3D-QSAR models will aid in giving better perceptions about structural requirements for developing newer anticancer agents.
[http://dx.doi.org/10.1016/j.ejmech.2016.09.093] [PMID: 27744184]
[http://dx.doi.org/10.1016/j.ejmech.2010.11.018] [PMID: 21146903]
[http://dx.doi.org/10.1093/mmy/myu098] [PMID: 25631481]