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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Current Strategies and Future Perspectives of Skin-on-a-Chip Platforms: Innovations, Technical Challenges and Commercial Outlook

Author(s): Ayça Bal-Öztürk*, Beatrice Miccoli, Meltem Avci-Adali, Ferzaneh Mogtader, Fatemeh Sharifi, Berivan Çeçen, Gökçen Yaşayan, Dries Braeken and Emine Alarcin*

Volume 24 , Issue 45 , 2018

Page: [5437 - 5457] Pages: 21

DOI: 10.2174/1381612825666190206195304

Price: $65

Abstract

The skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant endpoint for the application of pharmaceuticals. The area of in vitro skin tissue engineering has been progressing extensively in recent years. Advanced in vitro human skin models strongly impact the discovery of new drugs thanks to the enhanced screening efficiency and reliability. Nowadays, animal models are largely employed at the preclinical stage of new pharmaceutical compounds development for both risk assessment evaluation and pharmacokinetic studies. On the other hand, animal models often insufficiently foresee the human reaction due to the variations in skin immunity and physiology. Skin-on-chips devices offer innovative and state-of-the-art platforms essential to overcome these limitations. In the present review, we focus on the contribution of skin-on-chip platforms in fundamental research and applied medical research. In addition, we also highlighted the technical and practical difficulties that must be overcome to enhance skin-on-chip platforms, e.g. embedding electrical measurements, for improved modeling of human diseases as well as of new drug discovery and development.

Keywords: Skin-on-chip, In vitro skin model, Skin tissue engineering, Microfluidic, Drug discovery and development, skin impedance.

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