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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges

Author(s): Jatinder Kaur Mukker and Ravi Shankar Prasad Singh*

Volume 24 , Issue 43 , 2018

Page: [5175 - 5180] Pages: 6

DOI: 10.2174/1381612825666190130141310

Price: $65

Abstract

The properties of nanoparticles can be exploited to overcome challenges in drug delivery. By virtue of its design and size, the pharmacokinetics of nanoparticles are different than other small molecules. Modeling and simulation techniques have great potential to be used in nanoformulation development; however, their use in optimization of nanoformulation is very limited. This review highlights the differences in absorption, distribution, metabolism and excretion (ADME) characteristics of nanoparticles, use of modeling and simulation techniques in nanoformulation development and challenges in the implementation of modeling techniques.

Keywords: Nanoparticles, pharmacokinetics, modeling and simulations, PBPK modeling, microdialysis, drug delivery.


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