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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity

Author(s): Haibo Wang* and Xikui Liu

Volume 17, Issue 2, 2020

Page: [96 - 100] Pages: 5

DOI: 10.2174/1570178616666190126153703

Price: $65

Abstract

A novel bis-indole alkaloid was isolated from the flowers of Rauvolfia Yunnanensis Tsiang. Its structure was elucidated as 10,11´- dimethoxy-11,10´-bis-[N(a)-methyl deacetyldeformyl- 1,2- dihydro akuammiline(2β)] (1) on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESI-MS and comparison with data from the literature. The bis-indole alkaloid displayed more potent antihypertension activity and much lower hepatotoxicity in vivo than Reserpine.

Keywords: Alkaloid, Bis-indole alkaloid, Rauvolfia yunnanensis, rauvolfia flowers, antihypertension, reserpine.

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