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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Progress in Research on Brain Development and Function of Mice During Weaning

Author(s): Wenjie Zhang, Yueling Zhang, Yuanjia Zheng, Mingxuan Zheng, Nannan Sun*, Xiaoying Yang* and Yong Gao*

Volume 20 , Issue 7 , 2019

Page: [705 - 712] Pages: 8

DOI: 10.2174/1389203720666190125095819

Price: $65

Abstract

Lactation is a critical phase for brain function development. New dietary experiences of mouse caused by weaning can regulate brain development and function, increase their response to food and environment, and eventually give rise to corresponding behavioral changes. Changes in weaning time induce the alteration of brain tissues morphology and molecular characteristics, glial cell activity and behaviors in the offspring. In addition, it is also sensitive to the intervention of environment and drugs during this period. That is to say, the study focused on brain development and function based on mouse weaning is critical to demonstrate the underlying pathogenesis of neuropsychiatric diseases and find new drug targets. This article mainly focuses on the developmental differentiation of the brain during lactation, especially during weaning in mice.

Keywords: Wean, brain development, behavioral changes, neuron, glial cell, lactation.

Graphical Abstract
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