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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Drug Repurposing for Retinoblastoma: Recent Advances

Author(s): Kamakshi Dandu, Prathap R. Kallamadi, Suman S. Thakur* and Ch. Mohan Rao*

Volume 19, Issue 17, 2019

Page: [1535 - 1544] Pages: 10

DOI: 10.2174/1568026619666190119152706

Price: $65


Retinoblastoma is the intraocular malignancy that occurs during early childhood. The current standard of care includes chemotherapy followed by focal consolidative therapies, and enucleation. Unfortunately, these are associated with many side and late effects. New drugs and/or drug combinations need to be developed for safe and effective treatment. This compelling need stimulated efforts to explore drug repurposing for retinoblastoma. While conventional drug development is a lengthy and expensive process, drug repurposing is a faster, alternate approach, where an existing drug, not meant for treating cancer, can be repurposed to treat retinoblastoma. The present article reviews various attempts to test drugs approved for different purposes such as calcium channels blockers, non-steroidal antiinflammatory drugs, cardenolides, antidiabetic, antibiotics and antimalarial for treating retinoblastoma. It also discusses other promising candidates that could be explored for repurposing for retinoblastoma.

Keywords: Drug repurposing, Retinoblastoma, Calcium channel blockers, Cardenolides, NSAIDs, Antimalarials, Antidiabetics, Antibiotics.

Graphical Abstract
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