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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Research Progress of Glycyrrhizic Acid on Antiviral Activity

Author(s): Zhi-Gang Sun*, Ting-Ting Zhao, Na Lu, Yong-An Yang and Hai-Liang Zhu*

Volume 19, Issue 10, 2019

Page: [826 - 832] Pages: 7

DOI: 10.2174/1389557519666190119111125

Price: $65


Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. GA can significantly inhibit the proliferation of HIV, showing an immune activation. The clinical application of GA on the prevention and treatments of various diseases may derive from its numerous pharmacological properties. This review provides the summary of the antiviral effects of GA on research progress and mechanism in recent years.

Keywords: Glycyrrhizic acid, antiviral effects, hepatitis virus, HIV, influenza virus, herpes virus.

Graphical Abstract
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