Review Article

含岩藻糖的硫酸多糖作为生物医学支架的潜力

卷 26, 期 35, 2019

页: [6399 - 6411] 页: 13

弟呕挨: 10.2174/0929867326666181213093718

价格: $65

摘要

海洋环境具有大量的硫酸化多糖。在沿海地区,褐藻是生物质生产最丰富的地区,它们的细胞壁具有含岩藻糖的硫酸化多糖(FCSP),称为岩藻聚糖和/或岩藻依聚糖。这些硫酸化化合物的生物医学特性,即免疫调节,止血,病原体抑制,抗炎能力和抗肿瘤性已得到广泛研究。这些活性可能是由于它们模仿哺乳动物糖胺聚糖的碳水化合物部分的能力。因此,FCSP是用于健康相关主题的有趣化合物,主要用于开发用于递送系统或组织再生的支架。 FCSP还显示出了在这些应用中的潜力,这归因于它们与其他能够捕获治疗剂或细胞和生长因子的聚合物形成稳定的3D结构的能力,以及它们的生物相容性和生物降解性。然而,对于这些生物聚合物的临床使用,需要精确定义的可再现分子,以便准确地建立结构特征与人类健康应用之间的关系。

关键词: 岩藻糖,岩藻依聚糖,抗肿瘤,结构特征,输送装置,组织工程学。

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