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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Review Article

Idiopathic “Cyclic” Edema: A Frustrating and Poorly Understood Clinical Problem

Author(s): Thomas F. Whayne Jr* and Mary B. Fisher

Volume 16 , Issue 2 , 2018

Page: [88 - 93] Pages: 6

DOI: 10.2174/1871525717666181211141227

Price: $65


Idiopathic Edema (IE), is a syndrome involving real or perceived weight gain secondary to the pathological retention of fluid. This syndrome of generalized edema is almost solely reported in women. The diagnosis of IE is one of exclusion and requires a careful history, physical exam, and clinical suspicion. The aim of this article is to provide a comprehensive review of the available literature in order to attempt to define IE, identify the possible causes, review the proposed pathophysiology, and discuss potential treatment options.

Keywords: Capillary leak syndrome, compartment syndrome, cyclic edema, edema secondary to medications, hyponatremia, idiopathic edema, sodium concentration.

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