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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives

Author(s): Jaskirat Kaur, Divya Utreja*, Ekta, Nisha Jain and Shivali Sharma

Volume 16, Issue 1, 2019

Page: [17 - 37] Pages: 21

DOI: 10.2174/1570179415666181113144939

Price: $65


Background: Heterocyclic compounds containing nitrogen have been known to possess a very important role in the field of medicinal chemistry. Indole and its derivatives displayed a wide range of biological properties such as anti-inflammatory, analgesic, anti-microbial, anti-convulsant, antidepressant, anti-diabetic, antihelmintic and anti-allergic activities etc. The diverse biological activities exhibited by compounds containing indole moiety has provided the impetus to explore its anti-microbial activity in order to save the valuable life of patients.

Objective: The review focuses on the advances in the synthesis of indole derivatives and antimicrobial properties exhibited by them.

Conclusion: A great deal of work has been done in order to synthesize indole derivatives and to evaluate antimicrobial potential, as indicated by the review. The information provided in this article may be helpful for the researchers for the development of efficient antimicrobial drugs.

Keywords: Indole, heterocyclic, antimicrobial, antibacterial, antifungal, indole derivatives.

Graphical Abstract
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