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Current Medical Imaging


ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Research Article

Clinical Research on the Aortic Elasticity in Patients with Type 1 Diabetes Mellitus Complicated with Hypertension

Author(s): Zheng Wang and Yulei Wan*

Volume 15, Issue 6, 2019

Page: [585 - 588] Pages: 4

DOI: 10.2174/1573405614666181105095932


Objective: To investigate the characteristics of aortic elasticity in type 1 diabetes mellitus (DM1) patients with hypertension using dual-source computed tomography (DSCT).

Methods: Subjects were divided into four groups: 31 with hypertension (EH group), 28 with DM1 (DM1 group), 30 with hypertension and DM1 (DM1 + EH group), and 30 healthy volunteers (control group, CG). ECG-gated DSCT was used to measure the cross-sectional area of the aorta in diastole and systole and calculate the aortic elasticity (D). Analysis of variance and multiple linear regression were used for statistical analysis.

Results: Compared with the CG, aortic elasticity (D) in the DM1 group patients was not significantly decreased. Compared with the EH group, the DM1 + EH group showed no significant change. The aortic elasticity (D) in the EH and DM1 + EH groups was significantly lower than that in the CG and DM1 group.

Conclusion: DM1 slightly affects the aortic elasticity of the descending aorta, whereas hypertension exerts the main effect.

Keywords: X-ray computed tomography, hypertension, type 1 diabetes mellitus, thoracic aorta, elasticity, quantitative analysis.

Graphical Abstract
Giannattasio C, Failla M, Grappiolo A, et al. Progression of large artery structural and functional altera-tions in Type I diabetes. Diabetologia 2001; 44(2): 203-8.
van Elderen SG, Brandts A, Westenberg JJ, et al. Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: Assessment by magnetic resonance imaging. Eur Radiol 2010; 20(5): 1132-8.
Turkbey EB, Redheuil A, Backlund JY, et al. Aortic distensibility in type 1 diabetes. Diabetes Care 2013; 36(8): 2380-7.
Dogui A, Kachenoura N, Frouin F, et al. Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: A cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2011; 13(1): 11.
Nollen GJ, Westerhof BE, Groenink M, Osnabrugge A, van der Wall EE, Mulder BJ. Aortic pressure-area relation in Marfan patients with and without β blocking agents: A new non-invasive approach. Heart 2004; 90(3): 314-8.
O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE. Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 2002; 15(5): 426-44.
Li N, Beck T, Chen J, et al. Assessment of thoracic aortic elasticity: A preliminary study using electrocardiographically gated dual-source CT. Eur Radiol 2011; 21(7): 1564-72.
Liang W, Chen D, Chen W, Cheng G. The ascending aortic elasticity feature in normotensive subjects: Evaluation with coronary CT angiography. Clin Imaging 2014; 38(5): 686-92.
Jia CF, Jiang YN, Yang ZQ, et al. Ascending aortic elasticity and related risk factors study on prehypertension patients. Am J Hypertens 2017; 30(1): 61-6.
Sun G, Huang GH, Wang C, et al. Arterial function in patients with hypertension co-existed with type 2 diabetes mellitus. Chin J Hypertension 2007; 15(10): 835-8.
Blacher J, Safar ME. Large-artery stiffness, hypertension and cardiovascular risk in older patients. Nat Clin Pract Cardiovasc Med 2005; 2(9): 450-5.
Huvers FC, De Leeuw PW, Houben AJ, et al. Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions. Diabetes 1999; 48(6): 1300-7.
Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: A systematic review. Hypertension 2009; 54(6): 1328-36.
Mäkimattila S, Virkamäki A, Groop PH, et al. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation 1996; 94(6): 1276-82.
Poston L, Taylor PD. Glaxo/MRS Young Investigator Prize. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci (Lond) 1995; 88(3): 245-55.
Bagi Z, Koller A. Lack of nitric oxide mediation of flow-dependent arteriolar dilation in type I diabetes is restored by sepiapterin. J Vasc Res 2003; 40(1): 47-57.

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