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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Outer Membrane Proteins of Salmonella as Potential Markers of Resistance to Serum, Antibiotics and Biocides

Author(s): Bożena Futoma-Kołoch, Gabriela Bugla-Płoskońska*, Bartłomiej Dudek, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and Andrzej Gamian*

Volume 26 , Issue 11 , 2019

Page: [1960 - 1978] Pages: 19

DOI: 10.2174/0929867325666181031130851

Price: $65


Salmonellosis continues to be a significant worldwide health problem. Despite rapid progress in identifying mechanisms of Salmonella virulence and resistance to chemicals, our knowledge of these mechanisms remains limited. Furthermore, it appears that the resistance to antibiotics can be amplified by ubiquitous usage of the disinfectants (biocides), both by industry and by ordinary households. Salmonella, as other Gram-negative bacteria possess outer membrane proteins (OMPs), which participate in maintaining cell integrity, adapting to environment, and interacting with infected host. Moreover, the OMPs may also contribute to resistance to antibacterials. This review summarizes the role of OMPs in Salmonella serum resistance, antibiotics resistance and cross-resistance to biocides. Although collected data do not allow to assign OMPs as markers of the Salmonella susceptibility to the above-mentioned factors, some of these proteins retain a dominant presence in certain types of resistance.

Keywords: Antibiotics, disinfectants, molecular marker, outer membrane proteins, resistance, Salmonella, serum.

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