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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

The Mycobacterial HBHA Protein: A Promising Biomarker for Tuberculosis

Author(s): Flavio De Maio, Flavia Squeglia, Delia Goletti and Giovanni Delogu*

Volume 26 , Issue 11 , 2019

Page: [2051 - 2060] Pages: 10

DOI: 10.2174/0929867325666181029165805

Price: $65


A major goal in tuberculosis (TB) research is the identification, among the subjects infected with Mycobacterium tuberculosis (Mtb), of those with active TB, or at higher risk of developing active disease, from the latently infected subjects. The classical heterogeneity of Mtb infection and TB disease is a major obstacle toward the identification of reliable biomarkers that can stratify Mtb infected subjects based on disease risk. The heparin-binding haemagglutinin (HBHA) is a mycobacterial surface antigen that is implicated in tuberculosis (TB) pathogenesis. The host immune response against HBHA varies depending on the TB status and several studies are supporting the role of HBHA as a useful biomarker of TB.

Keywords: Tuberculosis, biomarkers, HBHA, personalized medicine, Mycobacterium tuberculosis (Mtb), MDR-TB.

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