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Current Enzyme Inhibition


ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Research Article

Antispermatogenic Effect of Piper betel Leaf Stalk Extract with Reference to Kinetic Studies of 17β-hydroxy Steroid Dehydrogenase Enzyme in Testes of Albino Rats

Author(s): Govardhan Naik Amgoth, P. Venkataramanaiah and Changamma Challa*

Volume 15 , Issue 1 , 2019

Page: [36 - 40] Pages: 5

DOI: 10.2174/1573408014666181018113911

Price: $65


Background: In the development and maintenance of male reproductive function and fertility, steroidogenesis plays a key role.

Aims: The aim of the present study was to investigate the effect of the betel leaf stalk extract on 17β- hydroxy steroid dehydrogenase activity levels.

Methods: The observed elevation in testicular cholesterol levels may be due to decreased androgen production, which resulted in impaired spermatogenesis. The decreased steroidogenic enzyme 17β- HSD activity represents decreased androgen production by the extract administration. Reduction in enzyme active site density and Km value revealed that there was a reduction in enzyme-substrate affinities and rate of E-S complex breakdown in the administered rat testes.

Results & Conclusion: The administration of betel leaf stalk extract resulted in decreased enzyme content probably through impaired synthesis.

Keywords: 17β-HSD, Betel leaf stalk extract, cholesterol, kinetic studies, spermatogenesis, steroidogenesis.

Graphical Abstract
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