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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Review Article

Progress in Synthesis and Bioactivity Evaluation of Pyrazoloquinazolines

Author(s): Hui Zhao, Xiaoxia Hu, Yue Zhang, Chunlei Tang* and Bainian Feng*

Volume 17, Issue 2, 2020

Page: [104 - 113] Pages: 10

DOI: 10.2174/1570180815666181017120100

Price: $65

Abstract

Background: This paper reviews the research progress of pyrazoloquinazolines which widely used in the field of medicine and pesticide in recent years. Five types of pyrazoloquinazolines are introduced: pyrazolo [4,3-h]quinazolines, pyrazolo[1,5-c]quinazolines, pyrazolo[4,3-f]quinazolines, pyrazolo[1,5-a] quinazolines , pyrazolo[1,5-b]quinazolines, and their new progress in the synthesis methods and treatment of diseases.

Methodology: The derivatives of pyrazoloquinazolines exhibit a wide range of pharmacological properties such as antibacterial, anticancer, antioxidants, anti-inflammatory, anti-diabetic, antiviral activities. Consequently, their syntheses have attracted significant interest. Various methodologies have been developed for the synthesis and functionalization of these class of compounds.

Conclusion: In the present article, the relevant and recent advances in the field will be briefly covered.

Keywords: Pyrazoloquinazolines, synthesis, bioactivity, diseases, anti-inflammatory, anti-diabetic.

Graphical Abstract
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