Generic placeholder image

Infectious Disorders - Drug Targets


ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Systematic Review Article

Human Fasciolosis in Iran: A Meta-analysis Study

Author(s): Masoud Behzadifar, Nicola Luigi Bragazzi, Meysam Behzadifar, Wesam Kooti, Ignazio Vecchio, Giulia Malaguarnera*, Mariano Martini and Farnaz Kheirandish

Volume 19, Issue 3, 2019

Page: [258 - 263] Pages: 6

DOI: 10.2174/1871526518666181017115028

Price: $65


Background: Fasciolosis, an infectious disorder with a serious public health burden, is caused by two liver flukes belonging to the genus Fasciola. Iran is among the endemic areas for this disease. This study aimed to determine the seroprevalence of human fasciolosis in Iran.

Methods: A systematic search was conducted in Embase, PubMed/MEDLINE, Web of Science (WoS), and Google Scholar, as well as Iranian databases including Scientific Information Database (SID), Magiran and Irandoc from January 2000 to June 2016. In order to determine fasciolosis prevalence, the DerSimonian-Laird random model was used. In order to assess the heterogeneity among studies, I2 and Q tests were used. To investigate the source of heterogeneity, meta-regressions based on the year of publication and sample size were performed. Sensitivity analysis was carried out to ensure the stability of obtained results.

Results: Eleven relevant studies were included. According to the data analysis a prevalence rate of 2% [95% CI 1-5] was found. No statistically significant relationship between gender and disease prevalence could be detected. We found an OR of developing fasciolosis of 1.67 [95% CI: 0.42 - 6.60] in people who had consumed vegetables versus those who did not eat vegetables, even though this did not yield statistical significance.

Conclusion: The findings of the current study can be valuable and help the health-care workers and policy-makers in programming and implementing ad hoc interventions in order to prevent the incidence of disease.

Keywords: Human fasciolosis, historical evolution in Iran, systematic review, meta-analysis, seroprevalence, prevalence.

Mas-Coma, S.; Bargues, M.D.; Valero, M.A. Fascioliasis and other plant-borne trematode zoonoses. Int. J. Parasitol., 2005, 35(11-12), 1255-1278.
[] [PMID: 16150452]
Nyindo, M.; Lukambagire, A.H. An Ongoing Zoonotic Trematode Infection. BioMed Res. Int., 2015.
Mekky, M.A.; Tolba, M.; Abdel-Malek, M.O.; Abbas, W.A.; Zidan, M. Human fascioliasis: a re-emerging disease in upper Egypt. Am. J. Trop. Med. Hyg., 2015, 93(1), 76-79.
[] [PMID: 25870421]
World Health Organization. Control of foodborne trematode infections: report of a WHO study group. Numero de informe: WHO technical report series., 848, 1995.
Pandya, S.S.; Hasnani, J.J.; Patel, P.V.; Chauhan, V.D.; Hirani, N.D.; Shukla, R.; Dhamsaniya, H.B. Study on prevalence of Fasciolosis in buffaloes at Anand and Ahmedabad districts, Gujarat, India. Vet. World, 2015, 8(7), 870-874.
[] [PMID: 27047167]
Esteban, J.G.; Gonzalez, C.; Curtale, F.; Muñoz-Antoli, C.; Valero, M.A.; Bargues, M.D.; el-Sayed, M.; el-Wakeel, A.A.; Abdel-Wahab, Y.; Montresor, A.; Engels, D.; Savioli, L.; Mas-Coma, S. Hyperendemic fascioliasis associated with schistosomiasis in villages in the Nile Delta of Egypt. Am. J. Trop. Med. Hyg., 2003, 69(4), 429-437.
[] [PMID: 14640504]
Curtale, F.; Abd El-Wahab Hassanein, Y.; El Wakeel, A.; Mas-Coma, S.; Montresore, A. Distribution of human fascioliasis by age and gender among rural population in the Nile Delta, Egypt. J. Trop. Pediatr., 2003, 49(5), 264-268.
[] [PMID: 14604157]
Rowan, S.E.; Levi, M.E.; Youngwerth, J.M.; Brauer, B.; Everson, G.T.; Johnson, S.C. The variable presentations and broadening geographic distribution of hepatic fascioliasis. Clin. Gastroenterol. Hepatol., 2012, 10(6), 598-602.
[] [PMID: 22373727]
Arauco, R.; Zetola, N.M.; Calderon, F.; Seas, C. Human fascioliasis: a case of hyperinfection and an update for clinicians. Foodborne Pathog. Dis., 2007, 4(3), 305-312.
[] [PMID: 17883314]
Keiser, J.; Utzinger, J. Food-borne trematodiases. Clin. Microbiol. Rev., 2009, 22(3), 466-483.
[] [PMID: 19597009]
Lotfy, W.M. Climate change and epidemiology of human parasitosis in Egypt: A review. J. Adv. Res., 2014, 5(6), 607-613.
[] [PMID: 25685530]
Dowlati, Y.; Dowlati, A.; Seyyedi, B. Cutaneous fascioliasis. Med. J. Islam. Repub. Iran, 1987, 1(1), 62-65.
Farid, H. Human infection with Fasciola hepatica and Dicrocoelium dendriticum in Isfahan area, central. Iran. J. Parasitol., 1972, 57, 160.
Moghaddam, A.S.; Massoud, J.; Mahmoodi, M.; Mahvi, A.H.; Periago, M.V.; Artigas, P.; Fuentes, M.V.; Bargues, M.D.; Mas-Coma, S. Human and animal fascioliasis in Mazandaran province, northern Iran. Parasitol. Res., 2004, 94(1), 61-69.
[] [PMID: 15338292]
Organization, W.H. The “neglected” neglected worms. Action Against Worms., 2007, 10, 1-8.
Moher, D.; Shamseer, L.; Clarke, M.; Ghersi, D.; Liberati, A.; Petticrew, M.; Shekelle, P.; Stewart, L.A. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst. Rev., 2015, 4(1), 1.
[] [PMID: 25554246]
Vandenbroucke, J.P.; von Elm, E.; Altman, D.G.; Gøtzsche, P.C.; Mulrow, C.D.; Pocock, S.J.; Poole, C.; Schlesselman, J.J. Egger, m. strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Int. J. Surg., 2014, 12(12), 1500-1524.
[] [PMID: 25046751]
DerSimonian, R.; Laird, N. Meta-analysis in clinical trials. Control. Clin. Trials, 1986, 7(3), 177-188.
[] [PMID: 3802833]
Higgins, J.P.; Thompson, S.G. Quantifying heterogeneity in a meta-analysis. Stat. Med., 2002, 21(11), 1539-1558.
[] [PMID: 12111919]
Egger, M.; Davey Smith, G.; Schneider, M.; Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315(7109), 629-634.
[] [PMID: 9310563]
Ashrafi, K.; Tahbaz, A.; Rahmati, B. Strongyloides stercoralis: The most prevalent parasitic cause of eosinophilia in gilan province, Northern Iran. Iran. J. Parasitol., 2010, 5(3), 40-47.
[PMID: 22347254]
Sarkari, B.; Ghobakhloo, N.; Moshfea, A.; Eilami, O. Seroprevalence of human fasciolosis in a new-emerging focus of fasciolosis in yasuj district, southwest of iran. Iran. J. Parasitol., 2012, 7(2), 15-20.
[PMID: 23109941]
Abdi, J.; Naserifar, R.; Rostami Nejad, M.; Mansouri, V. New features of fascioliasis in human and animal infections in Ilam province, Western Iran. Gastroenterol. Hepatol. Bed Bench, 2013, 6(3), 152-155.
[PMID: 24834263]
Asadian, S.; Mohebali, M.; Moudi, M.; Kia, E.; Heidari, Z.; Asgari, M.; Aryaeipour, M.; Radi, S.; Rokni, M.B. Seroprevalence of human fascioliasis in meshkin-shahr district, ardabil province, northwestern iran in 2012. Iran. J. Parasitol., 2013, 8(4), 516-521.
[PMID: 25516731]
Saberinasab, M.; Mohebali, M.; Molawi, G.; Beigom Kia, E.; Aryaeipour, M.; Rokni, M.B. Seroprevalence of human fascioliasis using indirect ELISA in isfahan district, central iran in 2013. Iran. J. Parasitol., 2014, 9(4), 461-465.
[PMID: 25759726]
Aryaeipour, M.; Kia, E.B.; Heidari, Z.; Sayyad Talaie, Z.; Rokni, M.B. Serological study of Human Fasciolosis in Patients Referring to the School of Public Health, Tehran University of Medical Sciences, Tehran, Iran during 2008-2014. Iran. J. Parasitol., 2015, 10(4), 517-522.
[PMID: 26811716]
Ashrafi, K.; Saadat, F.; O’Neill, S.; Rahmati, B.; Amin Tahmasbi, H.; Pius Dalton, J.; Nadim, A.; Asadinezhad, M.; Rezvani, S.M. The endemicity of human fascioliasis in guilan province, northern iran: the baseline for implementation of control strategies. Iran. J. Public Health, 2015, 44(4), 501-511.
[PMID: 26056669]
Hosseini, G.; Sarkari, B.; Moshfe, A.; Motazedian, M.H.; Abdolahi Khabisi, S. Epidemiology of human fascioliasis and intestinal helminthes in rural areas of boyer-ahmad township, southwest Iran; A Population Based Study. Iran. J. Public Health, 2015, 44(11), 1520-1525.
[PMID: 26744710]
Kheirandish, F.; Kayedi, M.H.; Ezatpour, B.; Anbari, K.; Karimi Rouzbahani, H.R.; Chegeni Sharafi, A.; Zendehdel, A.; Bizhani, N.; Rokni, M.B. Seroprevalence of human fasciolosis in pirabad, lorestan province, Western Iran. Iran. J. Parasitol., 2016, 11(1), 24-29.
[PMID: 27095965]
Manouchehri Naeini, K.; Mohammad Nasiri, F.; Rokni, M.B.; Kheiri, S. Seroprevalence of human fascioliasis in chaharmahal and bakhtiyari province, Southwestern Iran. Iran. J. Public Health, 2016, 45(6), 774-780.
[PMID: 27648421]
Marcos, L.; Maco, V.; Samalvides, F.; Terashima, A.; Espinoza, J.R.; Gotuzzo, E. Risk factors for Fasciola hepatica infection in children: a case-control study. Trans. R. Soc. Trop. Med. Hyg., 2006, 100(2), 158-166.
[] [PMID: 16181652]
Esteban, J.G.; Flores, A.; Angles, R.; Mas-Coma, S. High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. Trans. R. Soc. Trop. Med. Hyg., 1999, 93(2), 151-156.
[] [PMID: 10450437]
Bargues, M.D.; Funatsu, I.R.; Oviedo, J.A.; Mascoma, S. Natural water, an additional source for human infection by Fasciola hepatica in the Northern Bolivian Altiplano. Parasitologia., 1996, 38, 251.
Mas-Coma, S.; Valero, M.A.; Bargues, M.D. Chapter 2. Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control. Adv. Parasitol., 2009, 69, 41-146.
[] [PMID: 19622408]
Moghaddam, A.S.; Massoud, J.; Mahmoodi, M.; Mahvi, A.H.; Periago, M.V.; Artigas, P.; Fuentes, M.V.; Bargues, M.D.; Mas-Coma, S. Human and animal fascioliasis in Mazandaran province, northern Iran. Parasitol. Res., 2004, 94(1), 61-69.
[] [PMID: 15338292]
Moghaddam, A.S.; Massoud, J.F.; Mahmoudi, M.; Khoubbane, M.; Artigas, P.; Periago, M.V. Distributional outline of lymnaeid snails (gastropoda) in the fascioliasis endemic area of mazandaran. Acta Parasitol., 2004, 49(2), 145-152.

Rights & Permissions Print Export Cite as
© 2022 Bentham Science Publishers | Privacy Policy