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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Synthesis of Specific Protein Phosphatase Inhibitors, Tautomycin and Tautomycetin toward Structure-Activity Relationship Study

Author(s): H. Oikawa

Volume 9 , Issue 22 , 2002

Page: [2033 - 2054] Pages: 22

DOI: 10.2174/0929867023368818

Price: $65


The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.

Keywords: Protein, Phosphatase Inhibitors, Tautomycin, Tautomycetin, apoptosis

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