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Current Bioactive Compounds

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ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

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Research Article

Fluoxetine Inhibits Respiratory Growth of Candida glabrata and has Cytocidal Activity

Author(s): Kayla Spencer-Bakes and Ian Macreadie*

Volume 15, Issue 6, 2019

Page: [692 - 695] Pages: 4

DOI: 10.2174/1573407214666181003150237

Price: $65

Abstract

Background: Fluoxetine is a widely prescribed antidepressant that has associated antifungal activity.

Methods: This study examined the growth inhibitory and cytotoxic effects of fluoxetine on Candida glabrata.

Results: Fluoxetine inhibited growth of C. glabrata on media containing glucose as a carbon source: the inhibition was much greater when ethanol was the carbon source. In hypoosmotic conditions fluoxetine caused death of C. glabrata in one hour.

Conclusion: Fluoxetine inhibits fermentative and mitochondrial function of C. glabrata. It rapidly kills C. glabrata in hypoosmotic conditions.

Keywords: Candida glabrata, fluoxetine, selective serotonin reuptake inhibitor, antifungal.

Graphical Abstract

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