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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Rationally Engineered Proteins or Antibodies with Absent or Reduced Immunogenicity

Author(s): S. Tangri, C. LiCalsi, J. Sidney and A. Sette

Volume 9 , Issue 24 , 2002

Page: [2191 - 2199] Pages: 9

DOI: 10.2174/0929867023368647

Price: $65

Abstract

One challenge associated with the clinical use of protein therapeutics destined for chronic administration is the potential for the development of unwanted anti-drug immune reactions. The molecular basis for this reactivity is the binding of peptide fragments (epitopes) derived from the breakdown of the

Keywords: epitope, immunostealth, antibody, htl


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