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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Review Article

Chitosan in Biomedical Engineering: A Critical Review

Author(s): Shabnam Mohebbi, Mojtaba Nasiri Nezhad*, Payam Zarrintaj, Seyed Hassan Jafari, Saman Seyed Gholizadeh, Mohammad Reza Saeb* and Masoud Mozafari*

Volume 14, Issue 2, 2019

Page: [93 - 116] Pages: 24

DOI: 10.2174/1574888X13666180912142028

Price: $65


Biomedical engineering seeks to enhance the quality of life by developing advanced materials and technologies. Chitosan-based biomaterials have attracted significant attention because of having unique chemical structures with desired biocompatibility and biodegradability, which play different roles in membranes, sponges and scaffolds, along with promising biological properties such as biocompatibility, biodegradability and non-toxicity. Therefore, chitosan derivatives have been widely used in a vast variety of uses, chiefly pharmaceuticals and biomedical engineering. It is attempted here to draw a comprehensive overview of chitosan emerging applications in medicine, tissue engineering, drug delivery, gene therapy, cancer therapy, ophthalmology, dentistry, bio-imaging, bio-sensing and diagnosis. The use of Stem Cells (SCs) has given an interesting feature to the use of chitosan so that regenerative medicine and therapeutic methods have benefited from chitosan-based platforms. Plenty of the most recent discussions with stimulating ideas in this field are covered that could hopefully serve as hints for more developed works in biomedical engineering.

Keywords: Chitosan, biomaterial, biomedical engineering, stem cell, tissue engineering, gene therapy.

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