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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm

Author(s): Grzegorz Guła, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel A. Valvano and Zuzanna Drulis-Kawa*

Volume 26 , Issue 11 , 2019

Page: [1979 - 1993] Pages: 15

DOI: 10.2174/0929867325666180912110151

open access plus


The environment exerts strong influence on microbes. Adaptation of microbes to changing conditions is a dynamic process regulated by complex networks. Pseudomonas aeruginosa is a life-threating, versatile opportunistic and multi drug resistant pathogen that provides a model to investigate adaptation mechanisms to environmental changes. The ability of P. aeruginosa to form biofilms and to modify virulence in response to environmental changes is coordinated by various mechanisms including two-component systems (TCS), and secondary messengers involved in quorum sensing (QS) and c-di-GMP networks (diguanylate cyclase systems, DGC). In this review, we focus on the role of c-di-GMP during biofilm formation. We describe TCS and QS signal cascades regulated by c-di-GMP in response to changes in the external environment. We present a complex signaling network dynamically changing during the transition of P. aeruginosa from the free-living to sessile mode of growth.

Keywords: Pseudomonas aeruginosa, biofilm, two-component systems, diguanylate cyclase systems, quorum sensing signaling pathway, biomarker.

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