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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Clinical Trial

Anti-Obesity Effect of Lactoferrin; Subgroup Analysis Excluding Subjects with Obese and/or Hyper-LDL Cholesterolemia

Author(s): Tomoji Ono*, Michiaki Murakoshi and Akira Uchiyama

Volume 18, Issue 1, 2018

Page: [105 - 109] Pages: 5

DOI: 10.2174/1871522218666180530074349

Price: $65

Abstract

Background: Lactoferrin is a multifunctional protein found in breast milk. We previously reported the anti-obesity effects of enteric-coated lactoferrin (eLF).

Objective: As the previous study included some subjects with high Body Mass Index (BMI) or low-Density Lipoprotein cholesterol (LDL-Cho), we investigated the antiobesity effect of lactoferrin excluding those subjects.

Method: We conducted a subgroup analysis of a previous report excluding subjects with BMI ≥ 30 and/or hyper-LDL cholesterolemia.

Results: Of the total 26 subjects in the previous study, 7 in the eLF group and 6 in the placebo group match the above criteria. The subgroup analysis revealed a significant decrease in visceral fat in the eLF group at week 8 compared with that at week 0 (-10.2 cm2, P < 0.01); no differences were observed in the placebo group. The mean visceral fat was also lower in the eLF group at week 8 compared with the placebo group (-16.2 cm2, P < 0.01). A significant decrease in BMI was observed in the eLF group at week 8 (-0.38 kg/m2, P < 0.05) compared with that at week 0. No differences were observed in the placebo group. The mean BMI was also lower in the eLF group at week 8 compared with that in the placebo group (-0.60 kg/m2, P < 0.05).

Conclusion: eLF reduced visceral fat and BMI excluding subjects with obese and/or hyper- LDL cholesterolemia.

Keywords: Lactoferrin, enteric-coated, visceral fat, BMI, RCT trial, subgroup analysis.

Graphical Abstract

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