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Current Enzyme Inhibition


ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Research Article

Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates

Author(s): Imdat Aygul, Fatma Yaylaci Karahalil*, Ozkan Danis, Ayşe Ogan and Sevgi Kolayli

Volume 14 , Issue 3 , 2018

Page: [226 - 232] Pages: 7

DOI: 10.2174/1573408014666180903143132

Price: $65


Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The IC50 values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting the highest activity. The inhibition values for urease ranged 22.30 µM to 39.00 µM, the highest activity being observed in C5.

Conclusion: Comparing the inhibitions with standard inhibitors of the enzymes, while the samples exhibited moderate inhibitions against hCA I, high inhibition was determined against urease.

Keywords: Carbonic anhydrase, coumarin, inhibition, jack bean, synthesis compounds, urease.

Graphical Abstract

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