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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Fructose-1,6-bisphosphatase Inhibitors: A Review of Recent (2000- 2017) Advances and Structure-Activity Relationship Studies

Author(s): Sarbjit Singh, Dipesh S. Harmalkar , Yongseok Choi* and Kyeong Lee*

Volume 26 , Issue 29 , 2019

Page: [5542 - 5563] Pages: 22

DOI: 10.2174/0929867325666180831133734

Price: $65


Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90-95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.

Keywords: Fructose-1, 6-bisphosphatase inhibitors, type 2 diabetes, adenosine 5’-monophosphate, hyperglycemia, diabetes mellitus, chronic disease.

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